rs10849915 - CCDC63

Magnitude 2.2 · 3 studies on file

Reported associations

• Genome-wide association studies identify genetic loci related to alcohol consumption in Korean men. - The American journal of clinical nutrition (2011) · Baik I, Cho NH, Kim SH, Han BG, Shin C · PubMed 21270382

  Genome-wide association (GWA) studies regarding the quantitative trait of alcohol consumption are limited. The objective of the study was to explore genetic loci associated with the amount of alcohol consumed. We conducted a GWA study with discovery data on single nucleotide polymorphisms (SNPs) for 1721 Korean male drinkers aged 40-69 y who were included in an urban population-based cohort. Another sample that comprised 1113 male drinkers who were from an independent cohort enrolled in a rural area served as a resource for replication. At baseline (18 June 2001 through 29 January 2003), members of both cohorts provided information on average daily alcohol consumptions, and their DNA samples were collected for genotyping. We tested 315,914 SNPs of discovery data by using multivariate linea

• Genetic Contributors to Variation in Alcohol Consumption Vary by Race/Ethnicity in a Large Multi-Ethnic Genome-wide Association Study - Unknown journal (n.d.) · Unknown authors · PubMed 28485404

  ABSTRACT: Alcohol consumption is a complex trait determined by both genetic and environmental factors, and is correlated with the risk of alcohol use disorders. While a small number of genetic loci have been reported to be associated with variation in alcohol consumption, genetic factors are estimated to explain about half of the variance in alcohol consumption, suggesting that additional loci remain to be discovered. We conducted a genome-wide association study (GWAS) of alcohol consumption in the large Genetic Epidemiology Research in Adult Health and Aging (GERA) cohort, in four race/ethnicity groups: non-Hispanic Whites, Hispanic/Latinos, East Asians, and African Americans. We examined two statistically independent phenotypes reflecting subjects' alcohol consumption during the past y

• New Common and Rare Variants Influencing Metabolic Syndrome and Its Individual Components in a Korean Population - Unknown journal (n.d.) · Unknown authors · PubMed 29632305

  ABSTRACT: To identify novel loci for susceptibility to MetS, we conducted genome-wide association and exome wide association studies consisting of a discovery stage cohort (KARE, 1946 cases and 6427 controls), and a replication stage cohort (HEXA, 430 cases and 3,264 controls). For finding genetic variants for MetS, with its components, we performed multivariate analysis for common and rare associations, using a standard logistic regression analysis for MetS. From the discovery and replication GWA studies, we confirmed 21 genome-wide signals significantly associated with MetS. Of these 21, four were previously unreported to associate with any MetS components: rs765547 near LPL; rs3782889 in MYL2; and rs11065756 and rs10849915 in CCDC63. Using exome chip variants, gene-based analysis of rar

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