rs10843111 - CCDC91: higher PEF, more gene expression
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Key takeaways
- This variant is linked to higher peak expiratory flow in some individuals
- It may increase expression of CCDC91 in thyroid and skin tissues
- The association is strong with p=5e-16
Key takeaways
- This variant is linked to higher peak expiratory flow in some individuals.
- It may increase expression of CCDC91 in thyroid and skin tissues.
- The association is strong with p=5e-16.
What the research says A genome-wide association study found that the T allele of rs10843111 is associated with higher peak expiratory flow, a reported effect size of 8.1, p=5e-16 in about 406 thousand individuals [PMID 36914875]. Gene expression analysis shows that the variant increases CCDC91 expression in thyroid and skin tissues, with slopes of +0.33 and +0.30 respectively GTEx Portal.
Reported associations
- Peak expiratory flow: the variant is associated with higher values, reported effect size 8.1 p=5e-16 in about 406 thousand individuals [PMID 36914875].
Evidence quality The GWAS involved roughly 406 thousand participants and reported a strong association with the T allele of rs10843111 for peak expiratory flow, effect size 8.1 p=5e-16. No other studies are provided in this catalog, so replication is not yet available [PMID 36914875].
Tissue-specific expression effects
- CCDC91: increased expression in thyroid and skin sun exposed lower leg GTEx Portal.
Last lifestyle considerations on file for this variant.
Frequently asked questions
What does the rs10843111 variant do?
rs10843111 is a genetic change in CCDC91 that has been linked to higher peak expiratory flow and increased expression of the gene in thyroid and skin tissues.
Is this variant related to breathing problems?
The T allele of rs10843111 is associated with higher peak expiratory flow, which may improve breathing capacity but does not cause a disease.
Does the variant affect gene expression?
Yes, the variant increases CCDC91 expression in thyroid and skin tissues according to GTEx data.