rs10821163 - PHF2

Magnitude 4.5 · 1 study on file

Reported associations

• Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of posttraumatic stress disorder - Unknown journal (n.d.) · Unknown authors · PubMed 38637617

  ABSTRACT: Posttraumatic stress disorder (PTSD) genetics are characterized by lower discoverability than most other psychiatric disorders. The contribution to biological understanding from previous genetic studies has thus been limited. We performed a multi-ancestry meta-analysis of genome-wide association studies across 1,222,882 individuals of European ancestry (137,136 cases) and 58,051 admixed individuals with African and Native American ancestry (13,624 cases). We identified 95 genome-wide significant loci (80 novel). Convergent multi-omic approaches identified 43 potential causal genes, broadly classified as neurotransmitter and ion channel synaptic modulators (e.g., GRIA1, GRM8, CACNA1E), developmental, axon guidance, and transcription factors (e.g., FOXP2, EFNA5, DCC), synaptic stru

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