rs10816394 (LINC01505): deeper brain sulci
Upload your raw genetic data once, we'll show you which variants you carry and what the research says.
Key takeaways
- - rs10816394 is linked to deeper brain sulci
- - expression of ENSG00000237062 rises in testis
- - expression of ZNF462 falls in thyroid
Key takeaways
- rs10816394 is linked to deeper brain sulci
- expression of ENSG00000237062 rises in testis
- expression of ZNF462 falls in thyroid
What the research says A genome-wide association study finds the variant associated with deeper brain sulci, a reported effect size of 6.92, p=5e-12 in about 33 thousand individuals PMID 34910505. GTEx data shows increased expression of ENSG00000237062 in testis, a slope of +0.37, p=8.6e-24 GTEx.
Reported associations Brain sulci: deeper sulci are associated with the variant, a reported effect size of 6.92, p=5e-12 PMID 34910505.
Evidence quality The GWAS used about 33 thousand individuals and reported a strong association with the variant, effect size 6.92, p=5e-12 [PMID 34910505]. GTEx expression data is from 953 donors within a cis window, showing significant changes in two genes GTEx.
Tissue-specific expression effects
- ENSG00000237062: increased expression in testis
- ZNF462: decreased expression in thyroid
No lifestyle considerations on file for this variant.
Frequently asked questions
What does rs10816394 mean?
It is a genetic variant at the LINC01505 locus that has been associated with deeper brain sulci and changes in gene expression in testis and thyroid.
Is rs10816394 linked to health conditions?
The variant is not directly linked to any disease; it shows an association with brain structure and tissue expression.
Can this variant affect my health?
There are no known health effects reported for this variant in the data provided.