rs10786767 - SH3PXD2A TRAIL link
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Key takeaways
- rs10786767 is linked to higher TRAIL levels
- This variant increases SH3PXD2A expression in heart and skin tissues
- The GWAS effect size is 4.44 p=9e-6
Key takeaways
- rs10786767 is linked to higher TRAIL levels
- This variant increases SH3PXD2A expression in heart and skin tissues
- The GWAS effect size is 4.44 p=9e-6
What the research says The GWAS shows an association with TRAIL levels [PMID 38326779]. GTEx data indicates increased expression in heart left ventricle, skin sun exposed lower leg, skin not sun exposed suprapubic, and esophagus mucosa [GTEx Portal].
Reported associations
- TRAIL levels: the variant is associated with higher levels reported effect size 4.44 p=9e-6 n=318 [PMID 38326779].
Evidence quality The supplied studies do not report a direct trait association for this variant; the rsid appears via GWAS Catalog PMID 38326779.
Tissue- specific expression effects
- SH3PXD2A: increased expression in heart left ventricle, skin sun exposed lower leg, skin not sun exposed suprapubic, esophagus mucosa [GTEx Portal].
Lifestyle considerations on file for this variant.
Frequently asked questions
What does rs10786767 do?
It is a genetic variant that raises TRAIL levels and increases SH3PXD2A expression in heart and skin tissues.