Expressive

rs10756038 PTPRD NAFLD association

Key takeaways

  • The rs10756038 PTPRD G allele is linked to nonalcoholic fatty liver disease.
  • Effect size reported is 5.47 p=5e-8 in a large GWAS of about 691 thousand individuals.
  • This association is based on the G allele.

Key takeaways The rs10756038 PTPRD G allele is linked to nonalcoholic fatty liver disease. Effect size reported is 5.47 p=5e-8 in a large GWAS of about 691 thousand individuals. This association is based on the G allele.

What the research says The rs10756038 PTPRD G allele is associated with nonalcoholic fatty liver disease a reported effect size of 5.47 p=5e-8 in about 691 thousand individuals PMID 37709864. This is the only association described for this variant.

Reported associations Nonalcoholic fatty liver disease: The rs10756038 PTPRD G allele is associated with nonalcoholic fatty liver disease a reported effect size of 5.47 p=5e-8 in about 691 thousand individuals [PMID 37709864].

Evidence quality The supplied study is a GWAS catalog association involving about 691 thousand individuals reporting an effect size of 5.47 and p-value 5e-8 for the G allele associated with nonalocholic fatty liver disease [PMID 37709864]. No other studies were provided so replication status is unknown.

Lifestyle considerations No lifestyle considerations on file for this variant.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • Refined carbohydrates and added sugars Moderate

    High dietary refined carbohydrate and added sugar intake accelerates hepatic steatosis development in NAFLD-susceptible individuals

    Limit added sugars to <25g/day (women) or <36g/day (men); choose whole grains over refined carbs

Exercise

  • Aerobic and resistance exercise Moderate

    Physical activity improves insulin sensitivity, enhances fatty acid oxidation, and reduces hepatic lipid accumulation

    150 minutes moderate-intensity aerobic activity per week; add resistance training 2-3 days per week

Screening

  • Liver function testing and abdominal ultrasound Moderate

    PTPRD rs10756038 G-allele is strongly associated with increased NAFLD risk; baseline and periodic assessment enables early disease detection

    Baseline hepatic panel (ALT, AST, bilirubin, ALP) and abdominal ultrasound; repeat every 2-3 years

Frequently asked questions

What does rs10756038 mean?

rs10756038 is a genetic variant in the PTPRD gene that has been linked to nonalcoholic fatty liver disease.

Is this variant common or rare?

The G allele of rs10756038 is found at relatively high frequency and the association was detected in over 691 thousand people.

Can I change my risk?

This study only describes an association not a cause so lifestyle changes are not recommended.