rs10750486 - NTM

Magnitude 4.5 · 1 study on file

Reported associations

• Item-level analyses reveal genetic heterogeneity in neuroticism. - Nature communications (2018) · Nagel M, Watanabe K, Stringer S, Posthuma D, van der Sluis S · PubMed 29500382

  Genome-wide association studies (GWAS) of psychological traits are generally conducted on (dichotomized) sums of items or symptoms (e.g., case-control status), and not on the individual items or symptoms themselves. We conduct large-scale GWAS on 12 neuroticism items and observe notable and replicable variation in genetic signal between items. Within samples, genetic correlations among the items range between 0.38 and 0.91 (mean r = .63), indicating genetic heterogeneity in the full item set. Meta-analyzing the two samples, we identify 255 genome-wide significant independent genomic regions, of which 138 are item-specific. Genetic analyses and genetic correlations with 33 external traits support genetic differences between the items. Hierarchical clustering analysis identifies two geneti

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