CUX2 rs10744770: expression effect in tissues

Key takeaways

• This variant lies in the CUX2 locus.
• No direct trait association is reported for this SNP.
• Expression effects are observed in specific tissues according to GTEx data.
• Sample sizes are moderate with replication support.

What the research says The Strong Heart Family Study examined 256 participants without diabetes and found no significant association between rs10744770 and cardiometabolic traits [30369944]. The variant is located near PARP8 on chromosome 5 but does not show a direct effect on HOMA- B or insulin resistance. GTEx data shows expression changes in ADAM1B, LINC02356, TMEM116, ALDH2 and NAA25 GTEx Portal.

Reported associations

• CUX2: the variant is located in this gene region with no reported effect on CUX2 expression or function [30369944].

Evidence quality The supplied studies do not report a direct trait association for rs10744770; the rsid appears via Strong Heart Family Study. Sample sizes are 256 cases and 3244 replication participants.

Tissue- specific expression effects

• ADAM1B: increased expression in prostate GTEx Portal
• LINC02356: increased expression in spleen and lung GTEx Portal
• TMEM116: increased expression in muscle skeletal GTEx Portal
• ALDH2: decreased expression in skin sun exposed lower leg GTEx Portal
• NAA25: increased expression in adipose subcutaneous GTEx Portal

Lifestyle considerations No lifestyle considerations on file for this variant.