rs10739227 (LINC01505): ALPP Protein Levels Association

Key takeaways

• The rs10739227 variant is located in the LINC01505 region.
• Research links this variant to differences in ALPP protein levels.
• The association was observed in a large group of about 47,000 people.
• The statistical signal is highly significant, with a p-value of 9e-52.

What the research says A genome-wide analysis identified a statistical link between the rs10739227 variant and circulating ALPP protein levels PMID 39789286. The study examined approximately 47,000 individuals and found that carrying the T allele correlates with a reported effect size of 0.087, p=9e-52, in about 47 thousand individuals PMID 39789286. This association reached a p-value of 9e-52, indicating a strong statistical signal in the tested population PMID 39789286.

Reported associations

• ALPP protein levels: Carrying the T allele at this locus is associated with a reported effect size of 0.087 on circulating ALPP protein concentrations, based on data from roughly 47,000 participants, with a p-value of 9e-52 PMID 39789286.

Evidence quality The primary evidence comes from a single large-scale analysis involving approximately 47,000 individuals PMID 39789286. The reported p-value of 9e-52 meets standard thresholds for genome-wide significance, suggesting a robust statistical association within this cohort PMID 39789286. However, independent replication in separate populations is not documented in the supplied materials, leaving the broader generalizability of this finding unverified. The evidence is currently limited to this single dataset, and further studies would be needed to confirm the effect across diverse groups.

Lifestyle considerations No lifestyle considerations on file for this variant.