rs1057626 (XKR6): linked to cortical surface area
Upload your raw genetic data once, we'll show you which variants you carry and what the research says.
Key takeaways
- - The rs1057626 (XKR6) variant is associated with a small increase in cortical surface area
- - Two genes show reduced expression when this allele is present
- - The effect appears in multiple tissues across the genome
Key takeaways
- The rs1057626 (XKR6) variant is associated with a small increase in cortical surface area
- Two genes show reduced expression when this allele is present
- The effect appears in multiple tissues across the genome
What the research says This variant is linked to an increased cortical surface area and reduced expression of two genes 32193296.
Reported associations
- Cortical surface area: the variant is associated with a small increase in cortical surface area, reported effect size 13.76 p=9e-13 in about 33 thousand individuals 32193296.
- Gene expression: two genes show reduced expression when this allele is present GTEx Portal
Evidence quality The supplied studies do not report a direct trait association for this variant; the rsid appears via GWAS Catalog association.
Tissue- specific expression effects
- ENSG00000255310: reduced expression in whole blood, atrium appendage, sun-exposed lower leg, suprapubic skin GTEx Portal
- ENSG00000269918: reduced expression in whole blood, atrium appendage, sun-exposed lower leg, suprapubic skin GTEx Portal
Lifestyle considerations on file for this variant.
Frequently asked questions
What does rs1057626 mean?
rs1057626 (XKR6) is a single nucleotide change that is linked to higher cortical surface area and lower expression of two genes.
Is this variant harmful?
The studies do not indicate any disease or health risk associated with rs1057626.
Can I test for rs1057626?
Yes, it can be included in a DNA analysis that reports raw data interpretation.