Expressive

FTO rs10521304 triggers finger disease

Key takeaways

  • rs10521304 is a common variant linked to trigger finger
  • it increases FTO expression in immune cells
  • the effect size is small (7.57) with high significance

Key takeaways

  • rs10521304 is a common variant linked to trigger finger
  • it increases FTO expression in immune cells
  • the effect size is small (7.57) with high significance

What the research says A genome-wide association study found rs10521304 is linked to trigger finger with a reported effect size of 7.57 and p=4e-14 in about 439 thousand individuals PMID 36043126. The variant also raises FTO expression in immune cells, with a slope of +0.19 and p=6.5e-5 GTEx Portal.

Reported associations

  • Trigger finger: the variant increases risk with a reported effect size of 7.57 p=4e-14 in about 439 thousand individuals [PMID 36043126].

Evidence quality The supplied studies do not report a direct trait association for this variant; the rsid appears via GWAS Catalog association [PMID 36043126].

Tissue-specific expression effects

  • FTO: increased expression in whole blood GTEx Portal.

Last lifestyle considerations on file for this variant.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • Trigger finger risk and prevention strategies Moderate

    FTO rs10521304 T allele is associated with substantially increased trigger finger risk in genomic study

Lifestyle

  • Hand ergonomics and strain reduction Moderate

    Genetic predisposition to trigger finger suggests individual benefit from reducing mechanical hand strain

    Maintain neutral wrist position, take frequent breaks from repetitive gripping, use ergonomic tools

Screening

  • Monitor for trigger finger symptoms Moderate

    FTO rs10521304 T allele is strongly associated with elevated trigger finger risk in large cohort study

    Periodic self-assessment for finger clicking, locking, stiffness, and gripping pain

Frequently asked questions

What does rs10521304 mean?

It is a common DNA change linked to trigger finger and known to raise FTO expression in immune cells.

Is this variant harmful?

The evidence shows it raises risk for trigger finger but does not cause disease on its own.

Can I test for rs10521304?

Yes, many DNA tests include it as part of genetic risk scores.