rs10521304 - FTO
Magnitude 4.5 · 1 study on file
Reported associations
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Shared genetic susceptibility between trigger finger and carpal tunnel syndrome: a genome-wide association study - Unknown journal (n.d.) · Unknown authors · PubMed 36043126
ABSTRACT: Summary Background Trigger finger and carpal tunnel syndrome are the two most common non-traumatic connective tissue disorders of the hand. Both of these conditions frequently co-occur, often in patients with rheumatoid arthritis. However, this phenotypic association is poorly understood. Hypothesising that the co-occurrence of trigger finger and carpal tunnel syndrome might be explained by shared germline predisposition, we aimed to identify a specific genetic locus associated with both diseases. Methods In this genome-wide association study (GWAS), we identified 2908 patients with trigger finger and 436 579 controls from the UK Biobank prospective cohort. We conducted a case-control GWAS for trigger finger, followed by co-localisation analyses with carpal tunnel syndrome summ
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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Trigger finger risk and prevention strategies Moderate
FTO rs10521304 T allele is associated with substantially increased trigger finger risk in genomic study
Lifestyle
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Hand ergonomics and strain reduction Moderate
Genetic predisposition to trigger finger suggests individual benefit from reducing mechanical hand strain
Maintain neutral wrist position, take frequent breaks from repetitive gripping, use ergonomic tools
Screening
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Monitor for trigger finger symptoms Moderate
FTO rs10521304 T allele is strongly associated with elevated trigger finger risk in large cohort study
Periodic self-assessment for finger clicking, locking, stiffness, and gripping pain