rs10432351 (TEX41): White Blood Cell Count Association
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Key takeaways
- Large-scale studies link rs10432351 to modest changes in white blood cell count
- The variant shows a reported effect size of 0.013 across nearly one million participants
- Expression data ties the variant to altered activity for TEX41 in testis and GTDC1 in skin
- Current evidence highlights statistical population patterns rather than direct clinical guidance
Key takeaways
- The variant rs10432351 is located near the TEX41 gene and shows a strong statistical link to white blood cell count in large population studies.
- Research involving nearly one million participants reports a small but highly significant effect size of 0.013 for this association.
- Expression data indicates the variant influences how much TEX41 is active in testicular tissue and GTDC1 in sun-exposed lower leg skin.
- Current evidence focuses on population-level statistical patterns rather than direct clinical diagnosis or treatment guidance.
What the research says Population-scale genetic analyses have identified rs10432351 as a statistically significant marker for variation in white blood cell count PMID 40436827. The analysis included approximately 928,000 individuals and found that carriers of the effect allele A exhibit a reported effect size of 0.013 with a p-value of 1e-12 PMID 40436827. Independent expression mapping shows the variant correlates with altered activity levels for the TEX41 gene in testis tissue and the GTDC1 gene in sun-exposed lower leg skin.
Reported associations
- White blood cell count: Large-scale genomic screening links this variant to differences in circulating white blood cell levels, reporting an effect size of 0.013 and a p-value of 1e-12 across roughly 928,000 participants PMID 40436827.
Evidence quality The available evidence derives from a single large-scale genome-wide association study encompassing approximately 928,000 individuals, which provides substantial statistical power for detecting small phenotypic effects PMID 40436827. The reported p-value of 1e-12 meets standard thresholds for genome-wide significance, indicating a robust statistical signal within the analyzed cohort. While the sample size is extensive, the effect size remains modest, suggesting the variant accounts for a minor fraction of population-level variation in white blood cell counts. Independent replication cohorts and functional validation studies are not detailed in the supplied data, leaving the precise biological mechanism and long-term stability of this association open to further investigation.
Tissue-specific expression effects
- TEX41: Increased expression in testis tissue GTEx Portal
- GTDC1: Reduced expression in sun-exposed lower leg skin GTEx Portal
Lifestyle considerations No lifestyle considerations on file for this variant.
Frequently asked questions
What is rs10432351?
It is a common genetic variant located near the TEX41 gene that researchers have linked to population-level differences in white blood cell counts.
How strong is the link between this variant and white blood cell count?
Studies involving nearly one million people found a highly significant statistical connection, though the actual impact on cell counts remains quite small.
Does this variant affect gene activity in other parts of the body?
Yes, expression mapping shows it correlates with increased TEX41 activity in testicular tissue and reduced GTDC1 activity in sun-exposed lower leg skin.
Can this variant predict health outcomes for an individual?
No, the current research describes broad population trends and statistical associations rather than providing diagnostic or predictive information for specific people.