rs10429952 (LINC02869): Lung Function & Gene Expression

Key takeaways

• This variant is linked to lung function metrics measured after using a bronchodilator medication.
• Research involving roughly thirteen thousand people shows a small but measurable statistical association.
• The variant correlates with lower expression of the LINC02869 gene in testicular tissue.
• Current evidence comes from a single published study, so replication across larger cohorts remains necessary.

What the research says Genome-wide association studies have identified rs10429952 as a variant associated with the post bronchodilator FEV1/FVC ratio, a standard measure of lung airflow limitation. The analysis included approximately thirteen thousand participants and found a reported effect size of 0.012 with a p-value of 1e-6 for the T allele. Independent functional mapping indicates that this same genomic region influences the expression levels of the LINC02869 gene in specific tissues. PMID 26634245

Reported associations

• Post bronchodilator FEV1/FVC ratio: Carriers of the T allele show a reported effect size of 0.012 in a cohort of about 13 thousand individuals, with a p-value of 1e-6. PMID 26634245

Evidence quality The available evidence rests on a single published analysis comprising roughly 13 thousand participants PMID 26634245. The reported p-value of 1e-6 meets conventional thresholds for statistical significance in large-scale genetic studies, and the effect size of 0.012 suggests a modest contribution to the trait PMID 26634245. Because only one study was provided for evaluation, independent replication across diverse populations is required to confirm the robustness of this association. The evidence quality remains provisional until additional cohorts validate these findings.

Tissue-specific expression effects

• LINC02869: Reduced expression in the testis. GTEx Portal

Lifestyle considerations No lifestyle considerations on file for this variant.