rs10264275 - SDK1: PTSD risk and expression
Upload your raw genetic data once, we'll show you which variants you carry and what the research says.
Key takeaways
- rs10264275 is linked to post-traumatic stress disorder with a small effect size
- the SNP increases SDK1 expression in whole blood and brain regions
- evidence comes from a genome-wide association study and tissue data
Key takeaways rs10264275 is linked to post-traumatic stress disorder with a small effect size the SNP increases SDK1 expression in whole blood and brain regions evidence comes from a genome-wide association study and tissue data
What the research says A genome-wide association study found that the risk allele A of rs10264275 is associated with post-traumatic stress disorder with an effect size of 5.66 and a p value of 1e-8 in about 1.3 million individuals [38637617]. Tissue-specific expression analysis shows that the ALT allele increases SDK1 expression in whole blood, brain nucleus accumbens basal ganglia, breast mammary tissue, frontal cortex BA9 and colon transverse tissues GTEx Portal.
Reported associations Post-traumatic stress disorder: the variant increases risk with a reported effect size of 5.66 p=1e-8 in about 1.3 million individuals [38637617].
Evidence quality The supplied studies do not report any conflicting findings; the GWAS catalog association is based on 1.3 million individuals and the GTEx expression data are from a cis-window analysis with FDR<0.05.
Tissue-specific expression effects
- SDK1: increased expression whole blood, brain nucleus accumbens basal ganglia, breast mammary tissue, frontal cortex BA9, colon transverse GTEx Portal.
No lifestyle considerations on file for this variant.
Frequently asked questions
What does rs10264275 mean?
It is a genetic variant that has been associated with post-traumatic stress disorder and also raises the level of SDK1 in several tissues.
Is this SNP related to other conditions?
The data only show an association with PTSD; no other traits are reported for rs10264275.
Can I change my risk?
We do not prescribe or recommend any action based on this variant alone.