rs10237280 - HDAC9: cortical surface area link
Upload your raw genetic data once, we'll show you which variants you carry and what the research says.
Key takeaways
- rs10237280 is linked to cortical surface area
- the variant increases HDAC9 expression in several tissues
- GWAS shows a strong association in over 33 thousand people
Key takeaways
- rs10237280 is linked to cortical surface area
- the variant increases expression of HDAC9 in several tissues
- the GWAS shows a significant link in over 33 thousand people
What the research says A GWAS of about 33 thousand individuals found that the T allele is linked to cortical surface area, reporting a reported effect size of 12.73 and a p value of 1e-12 PMID 32193296. GTEx expression data show that the ALT allele increases HDAC9 expression in brain cortex, putamen basal ganglia, nerve tibial, breast mammary tissue, thyroid and skin sun exposed lower leg GTEx Portal.
Reported associations
- Cortical surface area - the T allele is linked to larger cortical surface area with a reported effect size of 12.73 and p=1e-12 [PMID 32193296].
Evidence quality The supplied studies include a GWAS catalog association in about 33 thousand individuals reporting a significant link with the T allele, effect size 12.73 p=1e-12 and no conflicting findings.
Tissue-specific expression effects
- HDAC9: increased expression in whole brain cortex, putamen basal ganglia, nerve tibial, breast mammary tissue, thyroid, and skin sun exposed lower leg GTEx Portal.
No lifestyle considerations on file for this variant.
Frequently asked questions
What does rs10237280 do?
It is associated with larger cortical surface area and higher HDAC9 expression.
Is this variant linked to disease?
The GWAS shows a significant link but no direct disease claim.
Does the effect apply to everyone?
The association was found in about 33 thousand people; individual risk cannot be predicted.