TEX41 rs10196836: cognitive and Alzheimer resilience
Upload your raw genetic data once, we'll show you which variants you carry and what the research says.
Key takeaways
- rs10196836 is linked to general cognitive ability with a small positive effect.
- The variant also shows modest association with resilience to Alzheimer's disease pathology.
- Expression of the TEX41 gene is reduced in adipose_subcutaneous.
Key takeaways
- rs10196836 is linked to general cognitive ability with a small positive effect.
- The variant also shows modest association with resilience to Alzheimer's disease pathology.
- Expression of the TEX41 gene is reduced in adipose_subcutaneous.
What the research says The GWAS catalog shows rs10196836 is associated with general cognitive ability with a reported effect size of 4.79 p=2e-6 in about 300 thousand individuals [29844566]. It also links to resilience to Alzheimer's disease pathology with an effect size of 0.096 p=2e-6 in about 1 thousand individuals [35552371].
Reported associations
- General cognitive ability: the variant is associated with a small positive effect on cognition reported as an effect size of 4.79 p=2e-6 in about 300 thousand individuals [29844566].
- Cognitive resilience to Alzheimer's disease pathology: the variant shows modest association with resilience to Alzheimer's disease pathology with an effect size of 0.096 p=2e-6 in about 1 thousand individuals [35552371].
Evidence quality The evidence comes from two genome-wide association study catalog entries. The first includes 300 thousand participants and reports a small effect size of 4.79 p=2e-6 for general cognitive ability [29844566]. The second uses about 1 thousand individuals and finds an even smaller effect size of 0.096 p=2e-6 for resilience to Alzheimer's disease pathology [35552371]. Both are GWAS catalog associations with no direct replication beyond the catalog.
Tissue-specific expression effects
- TEX41: reduced expression in adipose_subcutaneous GTEx Portal.
Last lifestyle considerations on file for this variant.
Frequently asked questions
What does rs10196836 mean?
rs10196836 TEX41 is a single nucleotide change in the TEX41 gene that has been linked to general cognitive ability and modest resilience to Alzheimer's disease pathology. The effect sizes are small and the evidence comes from genome-wide association studies.
Is rs10196836 related to Alzheimer's disease?
The variant is associated with a modest increase in resilience to Alzheimer's disease pathology according to one GWAS catalog study. It does not cause the disease itself.
Does this variant affect gene expression?
Yes, TEX41 expression is reduced in adipose tissue as shown by GTEx data.