NRXN3 rs10143998 increased expression in esophagus
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Key takeaways
- NRXN3 is a neural function gene.
- rs10143998 raises its expression in the esophagus and other tissues.
- No health association reported.
Key takeaways NRXN3 is a gene involved in neural function. rs10143998 is linked to higher expression in the esophagus and other tissues. No direct health association reported.
What the research says The variant rs10143998 is part of a set of SUD-shared genes identified in a large cross-substance use disorder meta-analysis that examined 220 loci across diverse populations [41057643]. The study notes these genes are highly expressed in brain regions such as the amygdala and cortex. Tissue-specific expression data from GTEx shows increased NRXN3 expression in the esophagus muscularis, gastroesophageal junction, coronary artery, tibial artery and testis [GTEx].
Reported associations No direct trait association reported for rs10143998; the variant appears via SUD-shared gene catalog.
Evidence quality The meta-analysis includes 220 loci from samples genetically similar to 1kg-EUR, 1kg-AFR and 1kg-AMR populations with a sample size of over 500 000 individuals. The reported effect sizes are small (e.g., polygenic scores give odds ratios 1.95-2.87) but the study is well replicated across ancestries [41057643].
Tissue-specific expression effects
- NRXN3: increased expression in whole blood, aorta, and thyroid GTEx Portal
Lifestyle considerations No lifestyle considerations on file for this variant.
Frequently asked questions
What does rs10143998 do?
It is a SNP that increases NRXN3 expression in several tissues such as the esophagus and testis.
Is this variant linked to disease?
No direct disease link has been found; it appears only as part of SUD-shared genes.
Can I change my behavior because of this SNP?
There is no evidence that the variant changes health or lifestyle choices.