rs10105578 (CSMD1): QTc interval change
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Key takeaways
- rs10105578 may affect QTc interval length after antipsychotic treatment
- the association has a reported effect size of 4280 and p=3e-6
- it was found in about 661 individuals studied.
Key takeaways
- rs10105578 may affect QTc interval length after antipsychotic treatment
- the association has a reported effect size of 4280 and p=3e-6
- it was found in about 661 individuals studied.
What the research says This variant is associated with Antipsychotic drug-induced QTc interval change in schizophrenia, reported effect size 4280, p=3e-6, in 661 individuals, risk/effect allele A. PMID 29064910 The association was observed in a genome-wide association study. PMID 29064910.
Reported associations QTc interval change in schizophrenia - the variant may lengthen this interval, effect size 4280 p=3e-6 PMID 29064910.
Evidence quality The study is a single GWAS with n=661 individuals, reporting an effect size of 4280 and p=3e-6; no replication data are available. PMID 29064910.
Last lifestyle considerations on file for this variant.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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CSMD1 genotype and antipsychotic dosing Moderate
CSMD1 rs10105578 risk allele is associated with greater QTc interval prolongation in response to antipsychotics in schizophrenia
If prescribed antipsychotics, discuss genetic risk with prescriber
Frequently asked questions
What does rs10105578 do?
rs10105578 is a genetic variant that may affect the length of the QTc interval, which can influence heart rhythm.
Is this variant linked to schizophrenia?
The study found an association between rs10105578 and changes in QTc after antipsychotic treatment, but it does not cause schizophrenia itself.
How many people were studied?
Researchers examined about 661 individuals for this variant.