Expressive

rs10081191 - PTPRN2

Magnitude 4.5 · 1 study on file

Reported associations

  • Genome‐wide association study identifies 7q11.22 and 7q36.3 associated with noise‐induced hearing loss among Chinese population - Unknown journal (n.d.) · Unknown authors · PubMed 33242228

    ABSTRACT: Abstract Noise‐induced hearing loss (NIHL) seriously affects the life quality of humans and causes huge economic losses to society. To identify novel genetic loci involved in NIHL, we conducted a genome‐wide association study (GWAS) for this symptom in Chinese populations. GWAS scan was performed in 89 NIHL subjects (cases) and 209 subjects with normal hearing who have been exposed to a similar noise environment (controls), followed by a replication study consisting of 53 cases and 360 controls. We identified that four candidate pathways were nominally significantly associated with NIHL, including the Erbb, Wnt, hedgehog and intraflagellar transport pathways. In addition, two novel index single‐nucleotide polymorphisms, rs35075890 in the intron of AUTS2 gene at 7q11.22 (com

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • Occupational noise exposure and career planning consultation Moderate

    Homozygous risk genotype substantially increases NIHL susceptibility; may warrant occupational and recreational counseling

Lifestyle

  • Hearing protection in occupational and recreational noise Moderate

    rs10081191 A allele increases NIHL susceptibility through reduced PTPRN2 expression in auditory brain regions

    Wear rated hearing protection in environments >85 dB; use in occupational and recreational loud activities

Screening

  • Baseline and periodic audiometric assessment Moderate

    Increased NIHL genetic susceptibility enables early hearing loss detection and preventive intervention

    Establish baseline hearing assessment by age 20-25; repeat annually if occupationally exposed to noise >85 dB