rs1006923 - TEX41: Arterial Stiffness & Gene Expression

Key takeaways

• The variant rs1006923 maps to the TEX41 gene and shows a strong statistical link to arterial stiffness index in large population studies.
• Research indicates the variant influences gene expression in heart tissue and peripheral nerves.
• Current evidence focuses on population-level genetic signals rather than direct clinical diagnostics.
• The broader genetic region also contains signals near FOXO1, C1orf21, MRVI1, and COL4A2, though TEX41 carries the primary signal.
• No lifestyle or dietary interventions are currently supported by direct genetic evidence for this specific variant.

What the research says Large-scale genome-wide association studies have identified rs1006923 as a statistically significant marker for arterial stiffness index, a non-invasive measure of how rigid the arterial walls are. The analysis included roughly 127,000 participants and found a highly significant association with a p-value of 5.3e-12. While the primary signal points to TEX41, the same genetic region also shows activity near several neighboring genes, including FOXO1, C1orf21, MRVI1, and COL4A2, which are involved in vascular function and smooth muscle regulation. The variant also correlates with altered gene expression in specific tissues, particularly reducing expression in heart atrial appendage and tibial nerve samples.

Reported associations

• Arterial stiffness index: The variant shows a strong statistical association with this measure of vascular rigidity, reaching a p-value of 5.3e-12 in a cohort of approximately 127,000 individuals. The reported effect size was not specified in the provided data. PMID 31235810
• Gene expression in heart and nerve tissue: The variant is linked to reduced expression of TEX41 in heart atrial appendage and tibial nerve samples. GTEx Portal

Evidence quality The primary evidence comes from a large genome-wide association study involving 127,121 participants of European ancestry, which reported a highly significant p-value of 5.3e-12 for the TEX41 locus. The statistical model adjusted for mean arterial pressure and used inverse normal transformation of the trait data. The signal remains robust against genomic inflation, indicating reliable statistical control. It is important to note that Study 1 appears in the catalog via shared methodology and phenotype assessment, but does not discuss rs1006923 or TEX41 directly. The current data establishes a population-level genetic correlation rather than a proven causal mechanism for disease progression. The variant operates within a broader locus that also flags FOXO1, C1orf21, MRVI1, and COL4A2, so disentangling the exact driver gene requires further functional validation.

Tissue-specific expression effects

• TEX41: Reduced expression in heart atrial appendage and tibial nerve. GTEx Portal

Lifestyle considerations No lifestyle considerations on file for this variant.