Expressive

rs1006923 - TEX41

Magnitude 2.2 · 2 studies on file

Reported associations

  • Genetic Association of Finger Photoplethysmography-Derived Arterial Stiffness Index with Blood Pressure and Coronary Artery Disease - Unknown journal (n.d.) · Unknown authors · PubMed 31070453

    ABSTRACT: Objective: Arterial stiffness index (ASI) is independently associated with blood pressure and coronary artery disease (CAD) epidemiologically. However, it is unknown whether these associations represent causal relationships. Here, we assess whether genetic predisposition to increased ASI is associated with elevated blood pressure and CAD risk. Approach and Results: We first performed a large-scale epidemiologic association of finger photoplethysmography-derived ASI in the UK Biobank, finding significant associations with systolic blood pressure (SBP; Beta 0.55mmHg, [95% CI, 0.45-0.65], P=5.77×10−24, N=137,858), diastolic blood pressure (DBP; Beta 1.05mmHg, [95% CI, 0.99-1.11], P=7.27×10−272, N=137,862), and incident CAD (HR 1.08 [95% CI, 1.04-1.11], P=1.5×10−6; N=3

  • Genome-wide association study identifies loci for arterial stiffness index in 127,121 UK Biobank participants - Unknown journal (n.d.) · Unknown authors · PubMed 31235810

    ABSTRACT: Arterial stiffness index (ASI) is a non-invasive measure of arterial stiffness using infra-red finger sensors (photoplethysmography). It is a well-suited measure for large populations as it is relatively inexpensive to perform, and data can be acquired within seconds. These features raise interest in using ASI as a tool to estimate cardiovascular disease risk as prior work demonstrates increased arterial stiffness is associated with elevated systolic blood pressure, and ASI is predictive of cardiovascular disease and mortality. We conducted genome-wide association studies (GWASs) for ASI in 127,121 UK Biobank participants of European-ancestry. Our primary analyses identified variants at four loci reaching genome-wide significance (P < 5 × 10−8): TEX41 (rs1006923; P =

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