SMYD3, variants, traits, and what the research shows

SMYD3 - what this gene does

Based on the variants catalogued here, SMYD3 appears across five broad trait themes in genome-wide association studies (GWAS - a study design that scans large numbers of people's genomes for variants statistically associated with a trait): neurological conditions, liver-related traits, mental health, cancer, and cardiovascular phenotypes. The specific biological mechanisms underlying these associations are not described in the available data.

Key takeaways

• Seven variants reach the highest recorded magnitude (4.50) and together span all five trait categories: neurological, liver, mental health, cancer, and cardiovascular.
• Mental health is the only trait represented by more than one top-magnitude variant, lending modest weight to a replicated signal in that domain.
• A total of 166 variants are on file; only 43 carry prior research summaries, so the full picture may grow as more data is reviewed.
• All signals here are population-level statistical associations - they do not predict outcomes for any individual.
• Effect sizes and sample sizes are not provided in the current dataset, so the clinical magnitude of these associations cannot be evaluated here.

Notable variants

Seven variants reach the highest magnitude on file (4.50). rs10924473 is associated with neurological traits, and rs12117389 with liver traits. Two variants - rs142593645 and rs6426297 - are independently linked to mental health, making this the only trait category with more than one top-magnitude signal and providing limited evidence of replication within this gene. rs184882817 is linked to cancer, and rs6656940 to cardiovascular traits. rs4654084 also reaches magnitude 4.50 but does not carry a specific trait label in the current dataset. A separate tier of variants at magnitude 3.00 - including rs1054051754, rs138004389, rs143716511, rs143920876, and rs144514515, among others - extends the catalogue, though their individual trait associations are not specified here.

Trait associations

This gene's catalogued variants touch five trait domains. Neurological traits are represented by rs10924473. Liver traits appear through rs12117389. Mental health is linked to both rs142593645 and rs6426297 - two independent top-magnitude variants converging on the same domain, which is a mild signal of replication though far from confirmation. Cancer-related traits are associated with rs184882817, and cardiovascular traits with rs6656940. The breadth across these five domains is noted, but no mechanistic detail is available in the current data.

Evidence quality

The strongest signals on file reach magnitude 4.50, and the two mental health variants (rs142593645 and rs6426297) represent the only within-gene replication visible in the current dataset. Of the 166 total variants catalogued for this gene, only 43 carry prior published summaries, meaning the majority of associations have not yet been individually reviewed. No effect sizes (such as odds ratios or beta coefficients) or study sample sizes are available here, so the clinical or biological magnitude of these signals cannot be gauged. The associations most likely originate from GWAS, which are hypothesis-generating by design and require independent replication in separate cohorts before any signal can be considered well-established.

What this is NOT

These variants are population-level statistical signals from association studies and are not deterministic predictors of any health outcome for any individual. This content does not prescribe, diagnose, or advise any course of action.