SDK1, variants, traits, and what the research shows

SDK1 - what this gene does

SDK1 has variants linked to six trait themes: mental health, liver conditions, cancer, neurological disorders, rare diseases, and cardiovascular health. Without additional mechanistic detail in the current summaries, this entry characterizes the gene through the trait patterns its variants point toward.

Key takeaways

• Variants in SDK1 span six trait categories: liver conditions, mental health, neurological disorders, cancer, cardiovascular health, and rare diseases
• Four separate liver-related variants represent the strongest within-gene replication signal in the current data
• Mental health and neurological associations each have multiple variants pointing in the same direction
• All top-ranked variants share the same preliminary evidence score - no single hit stands clearly above the rest
• These are population-level statistical signals, not deterministic predictions for any individual

Notable variants

The top 20 variants on file each carry an identical magnitude score of 4.50, reflecting a uniform tier of preliminary evidence. The liver-association cluster is the most internally replicated signal, anchored by rs11763336 and rs75714524 alongside two further liver-linked hits. Among the variants with published editorial pages, rs10264275 carries a mental health association and rs117906595 a cancer association. A second mental health variant, rs35791987, further corroborates that theme. Neurological trait links appear in rs78883746. Single-trait signals round out the picture: cardiovascular health in rs77562169 and rare disease in rs548832768.

Trait associations

Six broad trait themes emerge from the variant data. Liver conditions are the most recurrent, appearing across four independent variants - rs11763336, rs6977475, rs74328717, and rs75714524 - which lends relative strength to that signal compared with single-hit findings. Mental health associations are supported by two variants, rs10264275 and rs35791987. Neurological trait links appear across three variants: rs181767458, rs36076521, and rs78883746. Cancer (rs117906595), cardiovascular health (rs77562169), and rare disease (rs548832768, rs562258065) each appear in isolated or paired variant signals. Several of the 20 top-ranked variants carry no trait annotation yet, so the full phenotypic scope of this gene in current research is likely broader than what is captured here.

Evidence quality

Most variants in this gene appear to be GWAS (genome-wide association study - a method that scans thousands of people's genomes for variants statistically linked to a trait) findings, which report population-level signals rather than individual-level certainties. All 20 top-ranked variants share a magnitude score of 4.50; no effect sizes such as odds ratios or beta coefficients, and no study sample sizes, are available in the current data. The three variants with published editorial pages - rs10264275, rs11763336, and rs117906595 - have not yet been populated with detailed findings, limiting what can be reported here. The liver cluster of four variants represents the most internally replicated signal within this gene, but without cross-cohort validation it remains preliminary. The broader pool of 362 total variants on file, with only 30 carrying any prior research summaries, underscores how much of this gene's association landscape is still being mapped.

What this is NOT

These variants are population-level statistical associations identified in research studies - they are not deterministic predictors of any individual's health or disease risk. This entry does not prescribe, diagnose, or advise any course of action.