PDE3A, variants, traits, and what the research shows

PDE3A - what this gene does

Based on the variants catalogued here, PDE3A shows its strongest research signal across rare disease and cardiovascular trait themes, with secondary associations in immune function, cancer, and liver-related traits. Magnitude - a composite score used here to prioritize variants by effect size and evidence quality - reaches 5.50 for the top entries in this gene.

Key takeaways

• The highest-magnitude variants (5.50) in this gene cluster around both cardiovascular and rare disease categories.
• Five cardiovascular-linked variants share the top magnitude tier, suggesting a concentrated population-level signal in that trait area.
• Rare disease associations span multiple magnitude levels, from 5.50 down to 3.00, indicating a persistent signal across the evidence tiers.
• Secondary associations with immune, cancer, and liver traits are present at magnitude 4.50.
• All signals described here are population-level statistics - they are not individual predictions.

Notable variants

The top-tier cardiovascular entries - rs794726864, rs794726865, rs794726866, rs794726867, and rs794726868, all at magnitude 5.50 - form the densest cluster in this gene's profile. Four rare-disease-linked variants match the same level: rs151312475, rs200052001, rs372559314, and rs372953537. At magnitude 5.00, rs1592115698 extends the cardiovascular signal and rs2121515547 adds to the rare-disease group. At magnitude 4.50, rs11045392 is linked to immune traits, rs117487814 to cancer, and rs7136586 to liver-related traits.

Trait associations

The dominant trait themes are cardiovascular and rare disease, each represented by multiple high-magnitude variants - a density that strengthens the signal for both areas. The cardiovascular grouping includes five variants at magnitude 5.50 (rs794726864, rs794726865, rs794726866, rs794726867, rs794726868) plus an additional magnitude-5.00 entry (rs1592115698). The rare-disease grouping spans the 5.50 tier (rs151312475, rs200052001, rs372559314, rs372953537), a magnitude-5.00 entry (rs2121515547), and two magnitude-3.00 entries (rs1008149263, rs1038607383). Secondary trait areas include immune (rs11045392, magnitude 4.50), cancer (rs117487814 and rs147128222, magnitude 4.50), and liver (rs7136586, magnitude 4.50).

Evidence quality

Of 205 total variants on file, 46 carry prior research summaries - a moderate editorial coverage rate that indicates sustained genomic research interest. The highest-magnitude entries (5.50) appear across both cardiovascular and rare-disease categories. Published editorial pages exist for rs11611208, rs117487814, and rs11045392; however, their underlying detailed summaries were not available when this entry was compiled, meaning specific odds ratios, beta coefficients, or sample sizes cannot be reported here. The evidence base should therefore be treated as directional rather than definitive, and individual variant pages should be consulted for the fullest available data.

What this is NOT

These variants are population-level statistical signals derived from genome-wide association studies (GWAS - studies that scan many people's genomes for variants statistically associated with a trait) and are not deterministic predictors of any outcome for any individual. Nothing in this entry constitutes medical advice, a clinical diagnosis, or a recommendation to take any action.