NTM, variants, traits, and what the research shows

NTM - what this gene does

Variants in NTM have been linked across genome-wide association studies (GWAS - studies that scan large populations for genetic variants statistically associated with a trait) to a broad set of traits spanning cardiovascular health, cancer risk, immune function, mental health, liver biology, and kidney biology.

Key takeaways

• Variants in this gene have been associated with six distinct trait domains: cardiovascular, cancer, immune, mental health, liver, and kidney.
• Three independent top-tier variants are each linked to mental health traits - the most within-domain replication in this dataset.
• Two cardiovascular-associated variants have published research pages, indicating support from external literature.
• 128 variants are catalogued for this gene, with 13 reaching the highest magnitude tier (4.50) on file.
• All findings are population-level statistical associations, not deterministic health predictions for any individual.

Notable variants

The cardiovascular signal is carried by rs11827555 and rs12098973, both scored at magnitude 4.50 and both supported by published research pages. Mental health associations appear across three independent magnitude-4.50 variants - rs35974940, rs7942876, and rs992564 - a degree of within-domain replication that distinguishes this trait cluster from the single-variant signals seen for cancer (rs552221), immune function (rs145633549), liver (rs61903468), and kidney (rs73030374) traits. Two additional magnitude-4.50 variants - rs10750486 and rs111530275 - have published pages but carry no trait label in the current data.

Trait associations

Based on variant annotations on file, this gene's research footprint spans six domains. Cardiovascular traits are represented by rs11827555 and rs12098973 at the top magnitude tier. Cancer risk is flagged by rs145397878 and rs552221, also at magnitude 4.50. The mental health domain - covered by rs35974940, rs7942876, and rs992564 - is the only domain where multiple independent top-tier variants converge, lending modest within-dataset support to that signal. Single top-tier associations exist for immune function (rs145633549), liver-related traits (rs61903468), and kidney-related traits (rs73030374). A further seven magnitude-3.00 variants - rs1334919413, rs201935214, rs2540134909, rs368362251, rs376930803, rs533353213, and rs756339914 - are catalogued without trait labels.

Evidence quality

Of the 128 variants on file, 13 reach the top magnitude tier (4.50) and 33 carry prior research summaries. Four variants - rs10750486, rs111530275, rs11827555, and rs12098973 - have published research pages, indicating external literature backing. The remaining magnitude-4.50 entries are tagged with trait categories but lack per-variant effect sizes (such as odds ratios) and sample sizes in the current data, so they should be treated as preliminary GWAS signals pending full annotation. The mental health signal is the most replicated within this dataset - three variants at the same magnitude tier - but without linkage disequilibrium data (information about how correlated nearby variants are with each other) it is not yet possible to confirm they represent truly independent signals rather than correlated markers of the same underlying locus.

What this is NOT

These variants represent population-level statistical signals observed across large study cohorts; they describe tendencies in groups, not deterministic outcomes for any individual. Nothing on this page constitutes medical advice, a diagnosis, or a recommendation to take any action.