NRXN3, variants, traits, and what the research shows

NRXN3 - what this gene does

Based on the variants catalogued here, NRXN3 shows up across research spanning mental health, neurological conditions, cardiovascular traits, rare disease, cancer, and liver-related phenotypes.

Key takeaways

• The highest-magnitude variant on file is linked to a rare disease trait.
• Mental health is the most recurrently associated category, with five distinct variants flagging it.
• Cancer associations appear independently across four separate variants.
• Neurological and cardiovascular trait signals are also present in the data.
• These variants are population-level statistical associations - not individual health predictions.

Notable variants

The strongest signal on file is rs1057519451 (magnitude 5.50), linked to a rare disease trait. At magnitude 4.50, the next tier of variants includes mental health associations from rs10143998, rs11849937, and rs4903813; neurological associations from rs184135706 and rs7155434; a cardiovascular association from rs11624704; cancer associations from rs191983395, rs7153826, rs79570639, and rs8004168; and a liver-related signal from rs57014620. Lower-magnitude mental health signals appear at rs12432103 and rs1362976615.

Trait associations

Mental health is the most recurrently represented trait theme: rs10143998, rs11849937, rs4903813, rs12432103, and rs1362976615 all carry this association - recurrence across five independent variants carries more evidential weight than any single hit alone. Cancer associations appear across four variants (rs191983395, rs7153826, rs79570639, rs8004168). Neurological traits appear in two variants (rs184135706, rs7155434). Cardiovascular (rs11624704), rare disease (rs1057519451), and liver (rs57014620) each contribute a single-variant signal at this time.

Evidence quality

The highest-confidence signal is rs1057519451 at magnitude 5.50, indicating stronger combined effect size and evidence weight relative to the magnitude 4.50 cluster that contains most other variants. Four variants - rs10143998, rs112079849, rs11624704, and rs11849937 - have dedicated published pages, indicating more developed editorial coverage, though detailed summaries are not yet available in the current dataset. Specific sample sizes, odds ratios, and replication counts are not available for the full variant list. Most findings reflect GWAS (genome-wide association study - a scan of many people's genomes for variants statistically linked to a trait) signals, which are population-level estimates that require replication and clinical validation before they carry diagnostic weight.

What this is NOT

The variants described here are population-level statistical associations, not deterministic predictors of any health outcome for any individual. Nothing on this page constitutes medical advice, a diagnosis, or a recommended course of action.