MSRA, variants, traits, and what the research shows

MSRA - what this gene does

Variants in MSRA have been identified in genome-wide association studies (GWAS - large studies that scan many people's genomes for variants statistically linked to traits) across several trait categories, most prominently mental health conditions, but also cancer, respiratory, and kidney phenotypes. The current variant data does not include detailed mechanistic information, so this entry focuses on the trait associations the research has surfaced.

Key takeaways

• Five independent variants in this gene are each associated with mental health traits - the most replicated signal in this gene's dataset.
• Two variants link to cancer phenotypes; one each connects to respiratory and kidney traits.
• All highest-ranked variants carry a magnitude score of 4.50, reflecting strong statistical signals from large-scale genomic research.
• 243 variants in this gene are on file, with 29 carrying prior research summaries - indicating active ongoing investigation.
• These are population-level statistical associations, not predictions for any individual.

Notable variants

Five variants - rs17151565, rs17151854, rs6601430, rs7818437, and rs7832431 - each reach magnitude 4.50 and are linked to mental health traits, making this the most recurrent association in the dataset. On the cancer side, rs1962073 and rs75022775 also reach magnitude 4.50. rs117733692 is associated with respiratory traits and rs9329221 with kidney phenotypes, both at magnitude 4.50. rs11249994 has a dedicated published page and also scores at magnitude 4.50.

Trait associations

Mental health is the most prominent trait theme: five separate magnitude-4.50 variants - rs17151565, rs17151854, rs6601430, rs7818437, and rs7832431 - each carry this association. Multiple independent variants within the same gene pointing to the same broad trait category is generally considered a stronger signal than a single-variant finding. Cancer associations appear through rs1962073 and rs75022775, both at magnitude 4.50. A respiratory phenotype is linked to rs117733692, and a kidney phenotype to rs9329221. At a lower magnitude (3.00), rs1171413366 carries a rare disease association; the remaining magnitude-3.00 entries - rs1156932960, rs1342129348, rs1369282579, rs138517353, and rs144066044 - have no trait label in the current dataset.

Evidence quality

The fourteen variants at magnitude 4.50 represent the strongest signals on file, with the five converging mental health associations being particularly notable: independent variants in the same gene pointing to the same trait provide a degree of implicit replication that a single-variant finding cannot. However, the current dataset does not include odds ratios, beta coefficients, or cohort sample sizes for any of these variants, so precise effect sizes cannot be reported here. Several magnitude-4.50 variants - rs187276360, rs4840475, rs62491598, and rs759188048 - carry no trait label, leaving their clinical context uncharacterized. The breadth of 243 variants on file with 29 prior research summaries signals that this gene is under active investigation and the evidence base is likely to grow.

What this is NOT

These variants are population-level statistical signals from GWAS research - they describe tendencies observed across large groups and are not deterministic predictors of any health outcome for any individual. This entry does not prescribe, diagnose, recommend any action, or constitute medical advice of any kind.