rs11249994 - MSRA: kidney function link
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Key takeaways
- The MSRA variant is linked to changes in kidney function with a reported effect size of 5.84 and p=5e-9
- This association was found in about 1.5 million individuals
- The G allele may influence how kidneys filter blood
Key takeaways
- The MSRA variant is linked to changes in kidney function with a reported effect size of 5.84 and p=5e-9
- This association was found in about 1.5 million individuals
- The G allele may influence how kidneys filter blood
What the research says This variant is linked to estimated glomerular filtration rate (creatinine) with a reported effect size of 5.84 and p=5e-9 in about 1.5 million individuals [PMID 35710981]. The association suggests the G allele may influence kidney function.
Reported associations Estimated glomerular filtration rate (creatinine): this variant is linked to changes in kidney function with a reported effect size of 5.84 and p=5e-9 [PMID 35710981].
Evidence quality The association was based on a GWAS of about 1.5 million individuals and has not been replicated elsewhere [PMID 35710981]. The evidence is strong but limited to this study.
Tissue- specific expression effects
- PRSS55: increased expression in brain cerebellar hemisphere GTEx Portal
- LINC03022: increased expression in thyroid GTEx Portal
Lifestyle considerations No lifestyle considerations on file for this variant.
Frequently asked questions
What does the MSRA variant do?
It is associated with changes in kidney function based on a GWAS study.
Is this variant linked to any other health traits?
The evidence only shows an association with kidney function; no other traits are reported.
Can I change my risk by lifestyle?
There are no lifestyle considerations for this variant.