FAF1, variants, traits, and what the research shows

FAF1 - what this gene does

FAF1 is a human gene whose catalogued variants are associated with neurological, cardiovascular, mental health, and respiratory traits in population-level genetic research. The trait landscape here is broad, spanning four distinct categories, with the highest-magnitude signals concentrated in neurological and cardiovascular areas.

Key takeaways

• FAF1 variants are linked to four major trait categories: neurological, cardiovascular, mental health, and respiratory.
• Nine top-tier variants include three neurological signals, two cardiovascular signals, one mental health signal, and one respiratory signal.
• 164 variants are catalogued for this gene, with 51 carrying published research summaries.
• Most associations reflect population-level statistical patterns, not deterministic outcomes for any individual.
• Detailed effect sizes and replication data are not available for all variants in the current dataset.

Notable variants

The highest-magnitude variants on file all score at 4.50. Neurological trait associations appear in rs111253797, rs138364069, and rs572377290. Cardiovascular signals are recorded for rs149288352 and rs72690486. A mental health association is on file for rs3827730, and a respiratory association for rs553050641. Two additional high-magnitude variants - rs3789584 and rs74738164 - carry no specific trait label in the current dataset.

Trait associations

Neurological traits are the most represented at the top magnitude tier, with three separate variants - rs111253797, rs138364069, and rs572377290 - each at magnitude 4.50. Cardiovascular traits appear through two distinct variants, rs149288352 and rs72690486, both also at 4.50, suggesting this trait category is well-represented among the strongest signals. Mental health is represented by rs3827730 and respiratory traits by rs553050641. A second tier of variants at magnitude 3.00 - including rs143113861, rs199634797, rs201769100, rs201770728, and others - are on file without individual trait labels in the current dataset.

Evidence quality

Of 164 total variants catalogued, 51 carry published research summaries. Nine variants sit at the highest magnitude tier (4.50), with a second tier of at least eleven variants at magnitude 3.00, most lacking individual trait labels in the current dataset. Because detailed effect sizes, sample sizes, and replication status are not available in the current summary data, the robustness of individual associations cannot be fully characterized here; the neurological signals' appearance across three independent top-tier variants is the strongest structural pattern visible in the data, though replication across independent cohorts would be needed to confirm each finding.

What this is NOT

The variants listed here are population-level statistical signals from genetic association studies - they describe patterns across large groups, not outcomes for any individual. Nothing on this page constitutes medical advice, a diagnosis, or a recommendation to take any action.