CDH13, variants, traits, and what the research shows

CDH13 - what this gene does

Variants catalogued in CDH13 span trait themes including cancer, cardiovascular health, respiratory function, hormonal factors, neurological outcomes, kidney function, vision, and rare disease. Detailed functional summaries are not yet available for all variants on file; the content below reflects the trait landscape the research community has associated with this locus.

Key takeaways

• CDH13 has top variants linked to cancer, heart health, and respiratory function
• Two independent variants share a respiratory association, which can strengthen a signal in genetic research
• Trait links span eight domains including neurological, kidney, and vision
• All top-ranked variants carry the same magnitude score, reflecting consistent research interest across the locus
• These are population-level statistical associations - not personal health forecasts

Notable variants

Among the highest-magnitude entries on file, rs11644424 and rs8060632 carry cancer associations, while rs11860936 and rs8055236 are linked to cardiovascular traits. Respiratory signals appear through two separate variants - rs6563898 and rs77347308 - reinforcing that domain. Further notable entries include rs7193703 with a hormonal association, rs77894924 with a neurological association, rs72790173 with a kidney association, rs78714524 with a vision association, and rs186112434 with a rare disease association. All twenty top-ranked variants share a magnitude score of 4.50.

Trait associations

Cancer appears as a recurring theme through rs11644424 and rs8060632 - two distinct variants flagging the same domain. Cardiovascular traits are represented by rs11860936 and rs8055236. Respiratory associations from rs6563898 and rs77347308 share a trait theme across two independent variants, a pattern that can add confidence to a signal in genetic research. Additional associations on file include hormonal (rs7193703), neurological (rs77894924), kidney (rs72790173), vision (rs78714524), and rare disease (rs186112434). Several further variants - including rs12386026, rs1364301, rs139419280, rs6563954, rs7194615, rs72800254, rs78119716, rs80341283, and rs9933938 - are catalogued without a specific trait label in the current dataset.

Evidence quality

All 20 top variants carry a magnitude score of 4.50, suggesting moderate-to-strong effect sizes relative to typical GWAS (genome-wide association study - a research approach that scans many people's genomes for variants statistically associated with a trait) findings. Three variants - rs11644424, rs11860936, and rs12386026 - have published editorial pages indicating prior curation, though full summaries were not available for this entry. Detailed statistics such as odds ratios, beta coefficients, and cohort sizes are absent from the current dataset, so replication depth cannot be assessed here. The breadth of trait themes across 20 top variants is notable, but cross-domain GWAS signals can reflect pleiotropic loci (genes influencing multiple traits), population stratification, or other confounders - caution is warranted in interpretation.

What this is NOT

These variants are population-level statistical signals derived from studies of large groups and are not deterministic predictors of any health outcome for any individual. Nothing on this page constitutes medical advice, a diagnosis, or a recommendation for any action.