rs12386026 - CDH13

Magnitude 4.5 · 1 study on file

Reported associations

• Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2 - Unknown journal (n.d.) · Unknown authors · PubMed 20694014

  ABSTRACT: We combined two tuberculosis (TB) genome-wide association studies (GWAS) from Ghana and The Gambia with subsequent replication totalling 11,425 participants. A significant association with disease was observed at SNP rs4331426 located in a gene-poor region on chromosome 18q11.2 (P=6.8×10−9, OR=1.19, 95%CI=1.13-1.27). Our finding shows that GWAS can identify novel loci for infectious causes of mortality even in Africa where levels of linkage disequilibrium are particularly low. FULL TEXT: [INTRO] Tuberculosis (TB) causes significant morbidity and mortality world-wide with a high disease burden in sub-Saharan Africa. Although previous studies have indicated that susceptibility to pulmonary TB has a substantial genetic component, progress in the determination of contributing gen

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