CADM2, variants, traits, and what the research shows

CADM2 - what this gene does

CADM2 has variants linked to mental health, neurological, and cancer trait categories identified in genome-wide association studies (GWAS - large scans that test thousands of people's DNA for variants statistically associated with a trait). The available summaries do not detail specific mechanisms, so the account below is grounded entirely in the trait labels visible across the variant list.

Key takeaways

• Multiple variants in this gene have been associated with mental health and neurological traits in published genetic research
• Neurological traits represent the largest single-category cluster among the top-ranked variants
• Five separate top-ranked variants fall under mental health categories, suggesting recurring research interest in this gene across behavioral phenotypes
• A cancer-category association appears in one top-ranked variant and should be treated as a single, preliminary signal
• All associations are population-level statistical findings from large group studies, not individual health predictions

Notable variants

All top-ranked variants carry an equal association magnitude of 4.50. Among those with trait labels, mental health associations are noted at rs11127876, rs1448601, rs62250713, and rs6770622. Neurological signals appear at rs1248855, rs17518584, and rs73843290. A cancer-category signal is flagged at rs184589251.

Trait associations

This gene appears across three broad research categories. Mental health associations are represented by five top-ranked variants - rs11127876, rs1448601, rs62250713, rs62253086, and rs6770622 - and the recurrence of this label across independent loci strengthens the signal for this category. Neurological associations are the most represented, appearing across six variants: rs1248855, rs140323454, rs146282319, rs17518584, rs62261694, and rs73843290. A cancer-category association at rs184589251 is the only entry in that category among the top-ranked variants and should be interpreted as a preliminary, single-variant signal.

Evidence quality

All 20 top-ranked variants share an identical magnitude score of 4.50, and 337 variants are on file for this gene in total, with 36 carrying prior research summaries. Detailed per-variant data - including effect sizes such as odds ratios or beta coefficients, sample sizes, and replication status across independent cohorts - are not available in the current summaries, making it impossible to rank individual variants beyond their shared magnitude score or to characterize the strength and direction of any single signal. The appearance of both mental health and neurological trait labels across multiple independent variants suggests this genomic region has drawn consistent research attention, but replication and effect-size data are necessary before clinical relevance can be assessed.

What this is NOT

These variants are population-level statistical signals from large group studies, not deterministic predictors of health outcomes for any individual. Nothing on this page constitutes medical advice, a diagnosis, or a recommendation of any kind.