Expressive

rs12393627 - ARSL

Magnitude 2.2 · 2 studies on file

Reported associations

  • Genome-wide association study of body height in African Americans: the Women's Health Initiative SNP Health Association Resource (SHARe). - Human molecular genetics (2012) · Carty CL, Johnson NA, Hutter CM, Reiner AP, Peters U, Tang H, Kooperberg C · PubMed 22021425

    Height is a complex trait under strong genetic influence. To date, numerous genetic loci have been associated with height in individuals of European ancestry. However, few large-scale discovery genome-wide association studies (GWAS) of height in minority populations have been conducted and thus information about population-specific height regulation is limited. We conducted a GWA analysis of height in 8149 African-American (AA) women from the Women's Health Initiative. Genetic variants with P< 5 × 10(-5) (n = 169) were followed up in a replication data set (n = 20 809) and meta-analyzed in a total of 28 958 AAs and African-descent individuals. Twelve single-nucleotide polymorphisms (SNPs) representing 7 independent loci were significantly associated with height at P < 5 × 10(-8). We iden

  • Identification, Replication, and Fine-Mapping of Loci Associated with Adult Height in Individuals of African Ancestry - Unknown journal (n.d.) · Unknown authors · PubMed 21998595

    ABSTRACT: Adult height is a classic polygenic trait of high heritability (h 2 ∼0.8). More than 180 single nucleotide polymorphisms (SNPs), identified mostly in populations of European descent, are associated with height. These variants convey modest effects and explain ∼10% of the variance in height. Discovery efforts in other populations, while limited, have revealed loci for height not previously implicated in individuals of European ancestry. Here, we performed a meta-analysis of genome-wide association (GWA) results for adult height in 20,427 individuals of African ancestry with replication in up to 16,436 African Americans. We found two novel height loci (Xp22-rs12393627, P = 3.4×10−12 and 2p14-rs4315565, P = 1.2×10−8). As a group, height associations discovered in E

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