Expressive

rs12365709 (OR52B6/TRIM6): Memory GWAS Variant

Key takeaways

  • rs12365709, near OR52B6 and TRIM6, was examined in a sex-aware genetic study of late-life memory covering roughly 27,000 older adults.
  • The study ran separate genetic analyses for men and women to find memory variants that may act differently by sex.
  • Participants included both non-Hispanic White and non-Hispanic Black individuals across four cognitive aging cohorts.
  • Detailed effect sizes for this variant are not available in the study excerpt, so findings should be considered preliminary.

Key takeaways

  • rs12365709, near the OR52B6 and TRIM6 genes, was examined in a sex-aware genetic study of late-life memory performance covering roughly 27,000 older adults.
  • The study conducted separate genetic analyses for men and women to identify memory-associated variants whose effects may differ by sex.
  • Participants spanned both non-Hispanic White and non-Hispanic Black ancestries across four cognitive aging cohorts.
  • Detailed effect sizes and p-values for this specific variant are not present in the available study excerpt, so findings should be treated as preliminary.

What the research says rs12365709, located near OR52B6 and TRIM6, was studied as part of the largest sex-aware genome-wide association study (GWAS) of late-life memory to date, enrolling N = 11,942 males and N = 15,641 females from four cohort studies of cognitive aging and Alzheimer's disease (Eissman et al., Alzheimer's and Dementia, 2024). The study used harmonized memory composite scores to standardize measurement across cohorts, and performed both sex-stratified GWAS and sex-interaction GWAS to pinpoint variants whose relationship with memory may differ between men and women. The analytical scope also included sex-specific genetic correlations between memory and cardiovascular, immune, and education traits.

Reported associations

  • Late-life memory performance: rs12365709 was examined in a sex-stratified GWAS of memory in older adults (Eissman et al., Alzheimer's and Dementia, 2024; n approximately 27,583); specific directional effect estimates for this locus are not available in the provided study excerpt.

Evidence quality The source study enrolled approximately 27,583 participants drawn from four cognitive aging cohorts: 24,216 non-Hispanic White and 3,367 non-Hispanic Black individuals. Harmonized memory composite scores were used across cohorts to improve measurement comparability, and both sex-stratified and sex-interaction GWAS models were applied. The authors describe this as the largest sex-aware memory genetics analysis conducted to date. However, the specific p-value, effect direction, and magnitude of association for rs12365709 are not present in the available excerpt, and replication status for this particular locus is not described. Findings should be considered preliminary pending review of the full published results.

Lifestyle considerations No lifestyle considerations on file for this variant.

Frequently asked questions

What genes are near rs12365709?

rs12365709 is located near two genes: OR52B6 and TRIM6. These gene names serve as the primary identifiers for this genomic locus in published research.

Is rs12365709 associated with memory decline?

This variant was studied in a large sex-stratified genome-wide analysis of late-life memory performance in older adults. Specific association details for this locus are not fully described in the available study text, so any link to memory performance should be treated as preliminary.

What study examined rs12365709?

rs12365709 was included in a sex-stratified and sex-interaction genome-wide association study of late-life memory by Eissman and colleagues, published in Alzheimer's and Dementia in 2024, enrolling approximately 27,000 older adults from four cognitive aging cohorts.

Does sex affect how rs12365709 influences memory?

The study that examined this variant was specifically designed to detect genetic effects that differ between men and women, using both sex-stratified and sex-interaction models. The sex-specific results for rs12365709 in particular are not detailed in the available excerpt.

How large was the study that identified rs12365709?

The study enrolled approximately 27,583 participants total, including 11,942 males and 15,641 females, drawn from four cohort studies of cognitive aging and Alzheimer's disease.