rs12321906 - ATF7-NPFF, ATF7

Magnitude 2.2 · 1 study on file

Reported associations

• Identification, Replication, and Fine-Mapping of Loci Associated with Adult Height in Individuals of African Ancestry - Unknown journal (n.d.) · Unknown authors · PubMed 21998595

  ABSTRACT: Adult height is a classic polygenic trait of high heritability (h 2 ∼0.8). More than 180 single nucleotide polymorphisms (SNPs), identified mostly in populations of European descent, are associated with height. These variants convey modest effects and explain ∼10% of the variance in height. Discovery efforts in other populations, while limited, have revealed loci for height not previously implicated in individuals of European ancestry. Here, we performed a meta-analysis of genome-wide association (GWA) results for adult height in 20,427 individuals of African ancestry with replication in up to 16,436 African Americans. We found two novel height loci (Xp22-rs12393627, P = 3.4×10−12 and 2p14-rs4315565, P = 1.2×10−8). As a group, height associations discovered in E

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