Expressive

rs12317967 (TBX3-AS1/UBA52P7): Opioid Dosing Locus

Key takeaways

  • rs12317967 sits in a noncoding region containing TBX3-AS1, an antisense RNA gene, and UBA52P7, a ubiquitin-related pseudogene
  • This variant appeared in the context of a genome-wide study of therapeutic opioid dosing
  • No genome-wide significant association was reported for this specific variant in the available study text
  • The evidence base for rs12317967 is limited to a single study, and effect sizes for this locus have not been established
  • Additional replication studies are needed before any conclusions can be drawn

Key takeaways

  • rs12317967 sits in a noncoding region containing TBX3-AS1, an antisense RNA gene, and UBA52P7, a ubiquitin-related pseudogene
  • This variant appeared in the context of a genome-wide study of therapeutic opioid dosing
  • No genome-wide significant association was reported for this specific variant in the available study text
  • The evidence base for rs12317967 is limited to a single study, and effect sizes for this locus have not been established
  • Additional replication studies are needed before any conclusions can be drawn

What the research says Only one study was retrieved for this variant: a genome-wide association study (GWAS, a method that surveys hundreds of thousands of genetic variants across the genome without a prior hypothesis) of therapeutic opioid dosing. The study examined daily methadone maintenance dose in individuals with opioid dependence (mean 68.0 mg per day in African-American subjects, n = 383; mean 77.8 mg per day in European-American subjects, n = 1,027) and morphine dose in opioid-naive children treated for surgical pain (n = 241). The available study text did not report specific association statistics for rs12317967 at the TBX3-AS1 / UBA52P7 locus.

Reported associations

  • Therapeutic opioid dosing: This variant was retrieved in the context of a GWAS of daily methadone dose in subjects with opioid dependence and morphine analgesic dose in opioid-naive children; the study's primary genome-wide significant hit was a separate variant near OPRM1 (the gene encoding the mu-opioid receptor) in African-American subjects (n = 383, p = 2.8 x 10^-8, each minor allele corresponding to approximately 20 mg per day of additional oral methadone), not at this locus, and no specific association statistics for rs12317967 were reported in the available text

Evidence quality The single retrieved study was a GWAS including 383 African-American subjects with opioid dependence, 1,027 European-American subjects with opioid dependence, and 241 opioid-naive children used for morphine dose follow-up. The study's primary genome-wide significant finding was a variant near OPRM1 in African-American subjects at p = 2.8 x 10^-8. No genome-wide significant associations were found in European-American subjects for any variant. Because no specific p-value, odds ratio, or effect size for rs12317967 was reported in the available text, the evidence quality for this specific locus must be rated as absent to preliminary. Replication of any association with opioid dosing phenotypes has not been demonstrated for this variant.

Lifestyle considerations No lifestyle considerations on file for this variant.

Frequently asked questions

What is TBX3-AS1?

TBX3-AS1 is an antisense RNA gene, meaning it is transcribed from the strand of DNA opposite to the TBX3 gene. Antisense RNA genes can play regulatory roles in gene expression, though the specific biological function of TBX3-AS1 is not described in the available research.

What is UBA52P7?

UBA52P7 is a pseudogene related to UBA52, which encodes a ubiquitin protein. Pseudogenes are DNA sequences that resemble functional genes but are generally not expressed as functional proteins. Its role near rs12317967 has not been described in the available research.

Is rs12317967 associated with opioid dosing?

rs12317967 was retrieved in the context of an opioid dosing genome-wide association study, but the study's primary genome-wide significant finding was a different variant near the OPRM1 gene. No specific association statistics for rs12317967 were reported in the available study text.

How much research has been done on rs12317967?

Only one study was retrieved for this variant: a genome-wide association study of therapeutic methadone and morphine dosing in individuals with opioid dependence and opioid-naive children. The evidence base for this specific locus is currently very limited.

What is a genome-wide association study?

A genome-wide association study (GWAS) surveys hundreds of thousands of genetic variants across the genome simultaneously, without a prior hypothesis about which genes matter. It identifies statistical associations between variants and a measured trait, such as daily opioid dose, in large groups of people.