rs1222884147 - SPATA31H1
Magnitude 2.2 · 1 study on file
Reported associations
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A genome-wide study on gene-nutrient interactions for hyperuricemia in a large Korean cohort (KoGES) - Unknown journal (n.d.) · Unknown authors · PubMed 40835619
ABSTRACT: This study aimed to identify novel genetic variants associated with hyperuricemia risk across multiple nutrients by assessing significant gene-nutrient interactions using large-scale genome-wide association study (GWAS) data in the Korean population. A total of 48,007 individuals from the Korean Genome and Epidemiology Study dataset were included in the GWAS. Dietary intake was evaluated using a food frequency questionnaire. To identify genomic loci that interact with specific nutrients influencing hyperuricemia risk, we conducted a GWAS followed by gene-nutrient interaction analyses of genome-wide significant single-nucleotide polymorphisms (SNPs). Two SNPs with significant gene-nutrient interactions for specific nutrients were identified: rs113206751 in the Membrane-Assoc
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Bloodwork
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serum uric acid level Moderate
SPATA31H1 variant rs1222884147 is associated with elevated serum uric acid, a risk factor for gout and kidney disease
annually as part of metabolic screening
Diet
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adequate dietary cholesterol intake Moderate
Variant association with hyperuricemia is pronounced with low cholesterol intake; adequate cholesterol may mitigate hyperuricemia risk
maintain 2000-5000mg dietary cholesterol weekly from whole eggs, dairy, and lean meats
Discuss with your doctor
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baseline uric acid testing and hyperuricemia management Moderate
SPATA31H1 variant rs1222884147 carries significant association with hyperuricemia in genomic studies