rs113206751 - MARCHF1
Magnitude 4.5 · 1 study on file
Reported associations
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A genome-wide study on gene-nutrient interactions for hyperuricemia in a large Korean cohort (KoGES) - Unknown journal (n.d.) · Unknown authors · PubMed 40835619
ABSTRACT: This study aimed to identify novel genetic variants associated with hyperuricemia risk across multiple nutrients by assessing significant gene-nutrient interactions using large-scale genome-wide association study (GWAS) data in the Korean population. A total of 48,007 individuals from the Korean Genome and Epidemiology Study dataset were included in the GWAS. Dietary intake was evaluated using a food frequency questionnaire. To identify genomic loci that interact with specific nutrients influencing hyperuricemia risk, we conducted a GWAS followed by gene-nutrient interaction analyses of genome-wide significant single-nucleotide polymorphisms (SNPs). Two SNPs with significant gene-nutrient interactions for specific nutrients were identified: rs113206751 in the Membrane-Assoc
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Bloodwork
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Serum uric acid level Low
Carriers of rs113206751-A with high vitamin A intake demonstrate 1.63-fold elevated hyperuricemia risk; monitoring enables early detection of elevated uric acid
Annual uric acid screening; target <7.0 mg/dL (male), <6.0 mg/dL (female)
Diet
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Vitamin A intake restriction if carrying rs113206751-A Low
High vitamin A stimulates IL-10 production, increasing MARCH1 expression in immune cells; MARCH1 dysregulation elevates mTOR signaling and serum uric acid levels
Limit vitamin A to dietary reference intake: 612.5 mcg/day (female), 737.5 mcg/day (male)