rs12148180 (FMN1): Common Height-Associated Variant
Key takeaways
- rs12148180 is one of 12,111 common genetic variants tied to adult height in the largest height GWAS ever conducted, with data from 5.4 million people.
- The variant sits near FMN1 (Formin 1), a gene in a genomic region implicated in human stature.
- All 12,111 identified height variants together explain about 40% of height variation in people of European ancestry.
- Genetic height prediction based on these variants is 2 to 4 times weaker in non-European populations, likely due to differences in allele frequencies across ancestry groups.
- No drug interactions or lifestyle factors have been specifically linked to this variant in the available evidence.
Key takeaways
- rs12148180 is one of 12,111 common genetic variants tied to adult height in the largest height GWAS ever conducted, with data from 5.4 million people.
- The variant sits near FMN1 (Formin 1), a gene in a genomic region implicated in human stature.
- All 12,111 identified height variants together explain about 40% of height variation in people of European ancestry.
- Genetic height prediction based on these variants is 2 to 4 times weaker in non-European populations, likely due to differences in allele frequencies across ancestry groups.
- No drug interactions or lifestyle factors have been specifically linked to this variant in the available evidence.
What the research says rs12148180, located near the FMN1 (Formin 1) gene, is one of 12,111 independent SNPs (single-nucleotide polymorphisms, meaning single-letter changes in the DNA sequence) significantly associated with adult height in a genome-wide association study (GWAS) of 5,380,080 individuals across 281 studies. The 12,111 variants cluster within 7,209 non-overlapping genomic segments averaging about 90 kilobases (90,000 base pairs) in length and together cover roughly 21% of the human genome. In out-of-sample prediction analyses, these variants collectively explain about 40% of the variation in height in populations of European ancestry but only around 10-20% in populations of other ancestries.
Reported associations
- Adult height: rs12148180 is among 12,111 common SNPs reaching genome-wide significance for human height in a GWAS of 5,380,080 individuals from diverse ancestries; the full set of SNPs collectively accounts for approximately 40% of height variance (the share of total variation in a trait explained by genetic factors) in European ancestry populations and 10-20% in other ancestry groups.
Evidence quality The study identifying rs12148180 used data from 5,380,080 individuals across 281 studies representing five major ancestry groups, making it one of the largest genetic studies ever conducted. All 12,111 reported SNPs reached genome-wide significance, and the authors describe this set as nearly saturating the common-variant heritability for height in European-ancestry populations. Prediction accuracy was substantially lower in non-European populations; the study attributes this to differences in linkage disequilibrium (the tendency for nearby genetic variants to be inherited together) and allele frequency (how common a particular version of a variant is in a population) across ancestries, rather than to different underlying biology. No specific per-variant effect size for rs12148180 alone is provided in the available study text, and no conflicting findings are reported within this study.
Lifestyle considerations No lifestyle considerations on file for this variant.
Frequently asked questions
What is rs12148180?
rs12148180 is a common single-nucleotide polymorphism (a single-letter change in the DNA sequence) located near the FMN1 gene. It was identified as one of 12,111 genetic variants significantly associated with adult height in a genome-wide study of over 5 million people.
What is the FMN1 gene?
FMN1 (Formin 1) is a gene whose chromosomal region has been implicated in height variation through large-scale genetic studies. rs12148180 is a variant near this locus that reached statistical significance in a height genome-wide association study of over 5 million participants.
Is rs12148180 linked to height?
Yes. rs12148180 was identified as one of 12,111 common genetic variants significantly associated with adult height in a genome-wide association study involving over 5 million participants from diverse ancestry groups.
How much does rs12148180 affect height?
The available study text does not report a specific effect size for rs12148180 alone. Collectively, all 12,111 identified height variants account for about 40% of the total variation in height in populations of European ancestry.
Does rs12148180 affect people of all ancestries equally?
The 12,111 height variants identified in the study explain about 40% of height variation in European ancestry populations but only around 10-20% in people of other ancestries. Researchers attribute this gap to differences in allele frequencies and linkage disequilibrium across ancestry groups, not to different underlying biology.