rs12126655 - VAV3

Magnitude 2.2 · 1 study on file

Reported associations

• A genome-wide association study on thyroid function and anti-thyroid peroxidase antibodies in Koreans. - Human molecular genetics (2016) · Kwak SH, Park YJ, Go MJ, Lee KE, Kim SJ, Choi HS, Kim TH, Choi SH, Lim S, Kim KW, Park DJ, Kim SS, Lee JY, Park KS, Jang HC, Cho NH · PubMed 24722205

  Genetic factors are thought to be an important determinant of thyroid function and autoimmunity. However, there are limited data on genetic variants in Asians. In this study, we performed a genome-wide association study on plasma thyroid-stimulating hormone (TSH) and free thyroxine (fT4) concentration and anti-thyroid peroxidase (anti-TPO) antibody positivity in 4238 Korean subjects. In the Stage 1 genome scan, 3396 participants from the Ansung cohort were investigated using 1.42 million genotyped or imputed markers. In the Stage 2 follow-up, 10 markers were genotyped in 842 participants from the Korean Longitudinal Study on Health and Aging cohort. An intronic variant in VAV3, rs12126655, which has been reported in Europeans, was significantly associated with plasma TSH concentration in t

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