Expressive

rs1207131288 - GCKR - SPATA31H1

Magnitude 2.2 · 1 study on file

Reported associations

  • A genome-wide study on gene-nutrient interactions for hyperuricemia in a large Korean cohort (KoGES) - Unknown journal (n.d.) · Unknown authors · PubMed 40835619

    ABSTRACT: This study aimed to identify novel genetic variants associated with hyperuricemia risk across multiple nutrients by assessing significant gene-nutrient interactions using large-scale genome-wide association study (GWAS) data in the Korean population. A total of 48,007 individuals from the Korean Genome and Epidemiology Study dataset were included in the GWAS. Dietary intake was evaluated using a food frequency questionnaire. To identify genomic loci that interact with specific nutrients influencing hyperuricemia risk, we conducted a GWAS followed by gene-nutrient interaction analyses of genome-wide significant single-nucleotide polymorphisms (SNPs). Two SNPs with significant gene-nutrient interactions for specific nutrients were identified: rs113206751 in the Membrane-Assoc

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • adequate protein intake Moderate

    Risk allele A is associated with hyperuricemia in low-protein dietary contexts; maintaining adequate protein intake may reduce this risk

    Ensure daily protein intake meets or exceeds recommended daily allowance (0.8 g/kg body weight)

  • adequate zinc intake Moderate

    Risk allele A is associated with hyperuricemia in low-zinc dietary contexts; maintaining adequate zinc intake may reduce this risk

    Ensure daily zinc intake meets recommended daily allowance (8 mg for women, 11 mg for men)

Discuss with your doctor

  • hyperuricemia risk and management strategy Moderate

    Genetic predisposition to hyperuricemia warrants personalized risk assessment and prevention planning

    Discuss baseline uric acid levels and individualized prevention approach with healthcare provider

Screening

  • uric acid level monitoring Moderate

    Genetic predisposition to hyperuricemia increases risk for gout and kidney complications; early detection enables preventive intervention

    Include serum uric acid in routine health screening