Expressive

rs11936395 - SLC2A9

Magnitude 2.0 · 3 studies on file

Reported associations

  • A genome-wide study on gene-nutrient interactions for hyperuricemia in a large Korean cohort (KoGES) - Scientific reports (2025) · Kim EY, Choi JE, Lee JW, Park JM, Song Y, Kwon YJ, Hong KW · PubMed 40835619

    ABSTRACT: This study aimed to identify novel genetic variants associated with hyperuricemia risk across multiple nutrients by assessing significant gene-nutrient interactions using large-scale genome-wide association study (GWAS) data in the Korean population. A total of 48,007 individuals from the Korean Genome and Epidemiology Study dataset were included in the GWAS. Dietary intake was evaluated using a food frequency questionnaire. To identify genomic loci that interact with specific nutrients influencing hyperuricemia risk, we conducted a GWAS followed by gene-nutrient interaction analyses of genome-wide significant single-nucleotide polymorphisms (SNPs). Two SNPs with significant gene-nutrient interactions for specific nutrients were identified: rs113206751 in the Membrane-Assoc

  • Diversity and longitudinal records: Genetic architecture of disease associations and polygenic risk in the Taiwanese Han population - Science advances (2025) · Liu TY, Lu HF, Chen YC, Liao CC, Lin YJ, Yang JS, Liao WL, Lin WD, Chen SY, Huang YC, Lin WY, Liu YH, Hsu KC, Chang SS, Chen HD, Chou YP, Chang JG, Wang CH, Chang CT, Huang CM, Yeo KJ, Wang TY, Yeh CC, Chen JH, Huang CP, Lai HC, Chen RH, Lin HJ, Wu PY, Wang JY, Kuo CC, Cho DY, Tsai CH, Tsai FJ · PubMed 40465716

    ABSTRACT: We addressed the underrepresentation of non-European populations in genome-wide association studies (GWASs) by building HiGenome, a large-scale genetic resource for the Taiwanese Han population. Using a custom genotyping array, we integrated deidentified electronic medical records (2003 to 2021) with genomic data to enable GWASs, phenome-wide association studies, and polygenic risk score (PRS) analysis. Among 413,000 participants, 323,397 passed ancestry and quality control filtering. GWASs covered 1085 traits, focusing on diseases prevalent in Taiwan such as type 2 diabetes, chronic kidney disease, gout, and alcoholic liver damage. PRSs were calculated for 238 traits, with the strongest associations observed in musculoskeletal disorders. Incorporating PRS into clinical practice

  • Analysis across Taiwan Biobank, Biobank Japan, and UK Biobank identifies hundreds of novel loci for 36 quantitative traits - Cell genomics (2023) · Chen CY, Chen TT, Feng YA, Yu M, Lin SC, Longchamps RJ, Wang SH, Hsu YH, Yang HI, Kuo PH, Daly MJ, Chen WJ, Huang H, Ge T, Lin YF · PubMed 38116116

    ABSTRACT: Summary Genome-wide association studies (GWASs) have identified tens of thousands of genetic loci associated with human complex traits. However, the majority of GWASs were conducted in individuals of European ancestries. Failure to capture global genetic diversity has limited genomic discovery and has impeded equitable delivery of genomic knowledge to diverse populations. Here we report findings from 102,900 individuals across 36 human quantitative traits in the Taiwan Biobank (TWB), a major biobank effort that broadens the population diversity of genetic studies in East Asia. We identified 968 novel genetic loci, pinpointed novel causal variants through statistical fine-mapping, compared the genetic architecture across TWB, Biobank Japan, and UK Biobank, and evaluated the utilit

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