rs11852029 (RNU7-51P): Multi-Trait GWAS Locus
Key takeaways
- rs11852029 sits in the RNU7-51P - RNU6ATAC28P region, which contains RNA pseudogene sequences
- It was flagged in a scan of 42 human traits looking for variants that affect more than one phenotype at once
- The scan used a 10% false discovery rate, meaning roughly 1 in 10 of the 341 identified loci may be a statistical false positive
- Specific trait associations and effect sizes for this variant have not been documented in the available research text
- Replication evidence in independent study populations is needed before any phenotypic claim can be confirmed
Key takeaways
- rs11852029 sits in the RNU7-51P - RNU6ATAC28P region, which contains RNA pseudogene sequences
- It was flagged in a scan of 42 human traits looking for variants that affect more than one phenotype at once
- The scan used a 10% false discovery rate (FDR), meaning roughly 1 in 10 of the 341 identified loci may be a statistical false positive
- Specific trait associations and effect sizes for this variant have not been documented in the available research text
- Replication evidence in independent study populations is needed before any phenotypic claim can be confirmed
What the research says A genome-wide comparison of GWAS (genome-wide association study) summary statistics across 42 human phenotypes identified 341 loci, at a false discovery rate of 10%, showing evidence of association with multiple traits. The studied phenotypes spanned a broad range including anthropometric measures such as body size, neurological diseases, and susceptibility to infection, with data drawn from 43 studies including 17 from the personal genomics company 23andMe, all conducted in individuals of European descent. Specific association data, including effect sizes and p-values, for rs11852029 within the RNU7-51P - RNU6ATAC28P region are not detailed in the provided study text.
Reported associations
- Multiple phenotypes (unspecified): This locus was identified within a multi-trait GWAS scan covering 42 conditions including anthropometric traits, neurological diseases, and infectious disease susceptibility; trait-specific effect data for rs11852029 are not available in the provided study text.
Evidence quality The source study (Pickrell JK, Berisa T, Liu JZ, Segurel L, Tung JY, Hinds DA; Nature Genetics, 2017) analyzed summary statistics from 43 GWAS covering 42 phenotypes in individuals of European descent, with the number of independent associated variants per study ranging from roughly 5 to over 500 depending on the trait. While the overall scan identified 341 loci at a 10% FDR, that threshold means approximately 1 in 10 of those reported associations across the full set may be false positives. The provided study text does not include trait-specific effect sizes, p-values, or replication data for rs11852029 in particular, making it impossible to assess the strength of evidence for any specific phenotypic association at this locus. Evidence should therefore be considered preliminary.
Lifestyle considerations No lifestyle considerations on file for this variant.
Frequently asked questions
What is rs11852029?
rs11852029 is a genetic variant in the RNU7-51P - RNU6ATAC28P region, which contains RNA pseudogene sequences. It was identified in a large study scanning 42 human traits for variants that appear to affect more than one phenotype.
What traits is rs11852029 associated with?
The variant was flagged in a broad multi-trait scan covering phenotypes from body size to neurological conditions to infection susceptibility, but specific confirmed trait associations for rs11852029 are not documented in the available research text.
What are RNU7-51P and RNU6ATAC28P?
These are RNA pseudogene designations that define the genomic region where rs11852029 is located. Pseudogenes are gene-like DNA sequences that typically do not produce functional gene products.
How reliable is the evidence for rs11852029?
The evidence is preliminary. The study that flagged this variant used a 10% false discovery rate across 341 loci, which means roughly 1 in 10 findings in that set could be a statistical false positive. Replication in independent study populations would be needed to confirm any specific association.
Is rs11852029 linked to any disease?
No specific disease links for this variant are documented in the available research text. It was identified in a general scan of 42 traits, but disease-specific findings for rs11852029 have not been reported in the provided study data.