rs11845867 - NPAS3

Magnitude 2.2 · 1 study on file

Reported associations

• A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci - Unknown journal (n.d.) · Unknown authors · PubMed 23817569

  [INTRO] Allergic disease is very common and carries substantial public health burdens. We conducted a meta-analysis of genome-wide association with self-reported cat, dust-mite, and pollen allergy in 53,862 individuals. We used generalized estimating equations to model shared and allergy-specific genetic effects. We identified 16 shared susceptibility loci with P<5×10−8, including 8 loci previously associated with asthma, as well as 4p14 near TLR1, TLR6, and TLR10 (rs2101521: P=5.3×−21); 6p21.33 near HLA-C and MICA (rs9266772: P=3.2×10−12); 5p13.1 near PTGER4 (rs7720838: P=8.2×10−11); 2q33.1 in PLCL1 (rs10497813: P=6.1×10−10); 3q28 in LPP (rs9860547: P=1.2×10−9); 20q13.2 in NFATC2 (rs6021270: P=6.9×10−9); 4q27 in ADAD1 (rs17388568: P=3.9×10−8); and 14q21.1 near FOXA

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