Expressive

rs10497813 - PLCL1

Magnitude 2.2 · 2 studies on file

Reported associations

  • A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci - Unknown journal (n.d.) · Unknown authors · PubMed 23817569

    [INTRO] Allergic disease is very common and carries substantial public health burdens. We conducted a meta-analysis of genome-wide association with self-reported cat, dust-mite, and pollen allergy in 53,862 individuals. We used generalized estimating equations to model shared and allergy-specific genetic effects. We identified 16 shared susceptibility loci with P<5×10−8, including 8 loci previously associated with asthma, as well as 4p14 near TLR1, TLR6, and TLR10 (rs2101521: P=5.3×−21); 6p21.33 near HLA-C and MICA (rs9266772: P=3.2×10−12); 5p13.1 near PTGER4 (rs7720838: P=8.2×10−11); 2q33.1 in PLCL1 (rs10497813: P=6.1×10−10); 3q28 in LPP (rs9860547: P=1.2×10−9); 20q13.2 in NFATC2 (rs6021270: P=6.9×10−9); 4q27 in ADAD1 (rs17388568: P=3.9×10−8); and 14q21.1 near FOXA

  • Multi-ancestry genome-wide association analyses identify novel genetic mechanisms in rheumatoid arthritis - Unknown journal (n.d.) · Unknown authors · PubMed 36333501

    ABSTRACT: Rheumatoid arthritis (RA) is a highly heritable complex disease with unknown etiology. Multi-ancestry genetic research of RA promises to improve power to detect genetic signals, fine-mapping resolution and performances of polygenic risk scores (PRS). Here, we present a large-scale genome-wide association study (GWAS) of RA, which includes 276,020 samples from five ancestral groups. We conducted a multi-ancestry meta-analysis and identified 124 loci (P < 5 × 10−8), of which 34 are novel. Candidate genes at the novel loci suggest essential roles of the immune system (for example, TNIP2 and TNFRSF11A) and joint tissues (for example, WISP1) in RA etiology. Multi-ancestry fine-mapping identified putatively causal variants with biological insights (for example, LEF1). Moreover, PRS

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