Expressive

rs11842874 - MCF2L

Magnitude 2.2 · 1 study on file

Reported associations

  • A variant in MCF2L is associated with osteoarthritis. - American journal of human genetics (2011) · Day-Williams AG, Southam L, Panoutsopoulou K, Rayner NW, Esko T, Estrada K, Helgadottir HT, Hofman A, Ingvarsson T, Jonsson H, Keis A, Kerkhof HJ, Thorleifsson G, Arden NK, Carr A, Chapman K, Deloukas P, Loughlin J, McCaskie A, Ollier WE, Ralston SH, Spector TD, Wallis GA, Wilkinson JM, Aslam N, Birell F, Carluke I, Joseph J, Rai A, Reed M, Walker K, Doherty SA, Jonsdottir I, Maciewicz RA, Muir KR, Metspalu A, Rivadeneira F, Stefansson K, Styrkarsdottir U, Uitterlinden AG, van Meurs JB, Zhang W, Valdes AM, Doherty M, Zeggini E · PubMed 21871595

    Osteoarthritis (OA) is a prevalent, heritable degenerative joint disease with a substantial public health impact. We used a 1000-Genomes-Project-based imputation in a genome-wide association scan for osteoarthritis (3177 OA cases and 4894 controls) to detect a previously unidentified risk locus. We discovered a small disease-associated set of variants on chromosome 13. Through large-scale replication, we establish a robust association with SNPs in MCF2L (rs11842874, combined odds ratio [95% confidence interval] 1.17 [1.11-1.23], p = 2.1 × 10(-8)) across a total of 19,041 OA cases and 24,504 controls of European descent. This risk locus represents the third established signal for OA overall. MCF2L regulates a nerve growth factor (NGF), and treatment with a humanized monoclonal antibody

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • NGF-targeted monoclonal antibody therapy for osteoarthritis Moderate

    MCF2L regulates nerve growth factor; anti-NGF antibodies reduce pain and improve function in knee osteoarthritis

    discuss emerging NGF-targeted biologic therapies with rheumatologist if osteoarthritis develops or limits function

Exercise

  • low-impact aerobic exercise and resistance training Moderate

    rs11842874-A increases osteoarthritis risk; regular exercise strengthens muscles supporting joints and reduces OA progression

    150 min/week low-impact aerobic exercise (swimming, cycling, walking) plus 2x resistance training

Screening

  • osteoarthritis screening and periodic assessment High

    rs11842874-A allele increases osteoarthritis risk 1.17-fold; early detection enables earlier intervention

    baseline joint clinical evaluation by age 45; repeat assessment every 3-5 years or if symptoms develop