Expressive

rs11823682 (TSPAN32): Genetic Variant Overview

Key takeaways

  • The single study provided does not report specific trait associations for rs11823682.
  • The study analyzed approximately 405,088 UK Biobank individuals across 13.3 million variants, covering 79 quantitative and 50 disease traits.
  • Quickdraws, the method used, identified 4.97% more quantitative trait associations and 3.25% more disease trait associations than REGENIE in the same dataset.
  • No effect sizes, odds ratios, or clinical significance data for this variant appear in the provided study materials.

Key takeaways

  • The single study provided does not report specific trait associations for rs11823682.
  • The study analyzed approximately 405,088 UK Biobank individuals across 13.3 million variants, covering 79 quantitative and 50 disease traits.
  • Quickdraws, the method used, identified 4.97% more quantitative trait associations and 3.25% more disease trait associations than REGENIE in the same dataset.
  • No effect sizes, odds ratios, or clinical significance data for this variant appear in the provided study materials.

What the research says The single provided study describes Quickdraws, a scalable genome-wide association study (GWAS) method that uses a spike-and-slab prior on variant effects and stochastic variational inference, applied to approximately 405,088 UK Biobank participants across 13.3 million variants and 129 traits (79 quantitative, 50 disease) (Loya H, Kalantzis G, Cooper F, Palamara PF, Nature Genetics, 2025). This study does not report specific findings for rs11823682 or the TSPAN32 gene region. No PMID was supplied for this source, so no inline citation link is available.

Reported associations

  • No variant-specific associations documented: The provided study material does not contain association data for rs11823682 or the TSPAN32 gene. Trait links, odds ratios, and effect sizes for this variant cannot be reported based on the available source.

Evidence quality The sole provided source (Loya H, Kalantzis G, Cooper F, Palamara PF, Nature Genetics, 2025) analyzed approximately 405,088 UK Biobank samples and 13.3 million genetic variants using the Quickdraws algorithm. This is a methods-focused paper describing gains in GWAS power, not a variant-specific report. Gains in replicated signals were noted in Biobank Japan and FinnGen for the method overall, but these replications are not specific to rs11823682. No PMID was supplied for this study. The evidence base for characterizing rs11823682 from the provided materials is absent; the evidence must be considered preliminary at best, pending publication of variant-specific results.

Lifestyle considerations No lifestyle considerations on file for this variant.

Frequently asked questions

What is rs11823682?

rs11823682 is a single nucleotide polymorphism, meaning a one-letter variation in the DNA code, located in or near the TSPAN32 gene. The study provided does not document specific trait associations for this variant.

Is rs11823682 linked to any diseases?

The provided study does not report disease associations for rs11823682. It is a methods paper analyzing large-scale UK Biobank genetic data and does not focus on this specific variant.

What is the TSPAN32 gene?

The provided study materials do not describe the function of TSPAN32. No functional annotation for this gene is available from the sources provided.

How was this variant studied?

The single provided study used the Quickdraws algorithm on approximately 405,088 UK Biobank participants analyzing 13.3 million variants, but this specific variant was not highlighted in the findings reported in the available text.