rs118124932 - IPCEF1
Magnitude 2.2 · 1 study on file
Reported associations
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Genome-wide association study identifies loci for arterial stiffness index in 127,121 UK Biobank participants - Unknown journal (n.d.) · Unknown authors · PubMed 31235810
ABSTRACT: Arterial stiffness index (ASI) is a non-invasive measure of arterial stiffness using infra-red finger sensors (photoplethysmography). It is a well-suited measure for large populations as it is relatively inexpensive to perform, and data can be acquired within seconds. These features raise interest in using ASI as a tool to estimate cardiovascular disease risk as prior work demonstrates increased arterial stiffness is associated with elevated systolic blood pressure, and ASI is predictive of cardiovascular disease and mortality. We conducted genome-wide association studies (GWASs) for ASI in 127,121 UK Biobank participants of European-ancestry. Our primary analyses identified variants at four loci reaching genome-wide significance (P < 5 × 10−8): TEX41 (rs1006923; P =
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Diet
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Mediterranean diet Moderate
Plant-based diets rich in antioxidants and polyphenols improve endothelial function
Emphasize vegetables, fruits, whole grains, fish, and olive oil
Exercise
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regular aerobic exercise Moderate
Aerobic exercise improves endothelial function and reduces arterial stiffness
Aim for 150 minutes of moderate aerobic activity per week
Screening
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arterial stiffness or cardiovascular assessment Moderate
Genetic variant associated with increased arterial stiffness, a cardiovascular disease risk factor
Discuss arterial stiffness measurement and cardiovascular risk assessment options with doctor