rs118106262 (PTPRD): asthma risk
Upload your raw genetic data once, we'll show you which variants you carry and what the research says.
Key takeaways
- This variant is linked to a higher risk of diisocyanate-induced asthma.
- The effect size is small (4.47) with p=8e-6 in about 898 individuals.
- Data come from the GWAS catalog.
Key takeaways
- This variant is linked to a higher risk of diisocyanate-induced asthma.
- The effect size is small (4.47) with p=8e-6 in about 898 individuals.
- Data come from the GWAS catalog.
What the research says This variant is associated with diisocyanate-induced asthma [PMID 25918132]. The effect size is 4.47 with p=8e-6 in about 898 individuals [PMID 25918132].
Reported associations Diisocyanate-induced asthma this variant increases risk with a reported effect size of 4.47 p=8e-6 in about 898 individuals [PMID 25918132].
Evidence quality The GWAS catalog study reports an association in 898 individuals with a small effect size and highly significant p-value indicating strong evidence for the link. No lifestyle considerations on file for this variant.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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occupational respiratory risk and protective measures Moderate
Occupational health assessment and personalized respiratory protection planning leverages genetic risk stratification to prevent asthma in susceptible workers
Discuss genetic risk and occupational exposure with occupational health physician for personalized protection planning
Lifestyle
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occupational diisocyanate exposure Moderate
G risk allele substantially increases susceptibility to diisocyanate-induced occupational asthma through altered immune response to industrial chemical exposure
Avoid or minimize occupational diisocyanate exposure through job modification or respiratory protection
Screening
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pulmonary function if diisocyanate-exposed Moderate
Regular spirometry and symptom monitoring can detect early airway changes in G allele carriers with occupational diisocyanate exposure
Annual spirometry and respiratory symptom assessment if occupationally exposed to diisocyanates
Frequently asked questions
What does rs118106262 mean?
rs118106262 is a genetic change in the PTPRD gene that has been associated with a small increase in risk of diisocyanate-induced asthma.
Is this variant dangerous?
The evidence shows a modest association but it does not indicate a high personal risk or any required action.
Can I change my lifestyle to avoid the effect?
There are no specific lifestyle recommendations for this variant; the link is genetic and not tied to diet or behavior.