Expressive

rs118106262 - PTPRD

Magnitude 4.5 · 1 study on file

Reported associations

  • Genome-Wide Association Study Identifies Novel Loci Associated With Diisocyanate-Induced Occupational Asthma. - Toxicological sciences : an official journal of the Society of Toxicology (2016) · Yucesoy B, Kaufman KM, Lummus ZL, Weirauch MT, Zhang G, Cartier A, Boulet LP, Sastre J, Quirce S, Tarlo SM, Cruz MJ, Munoz X, Harley JB, Bernstein DI · PubMed 25918132

    Diisocyanates, reactive chemicals used to produce polyurethane products, are the most common causes of occupational asthma. The aim of this study is to identify susceptibility gene variants that could contribute to the pathogenesis of diisocyanate asthma (DA) using a Genome-Wide Association Study (GWAS) approach. Genome-wide single nucleotide polymorphism (SNP) genotyping was performed in 74 diisocyanate-exposed workers with DA and 824 healthy controls using Omni-2.5 and Omni-5 SNP microarrays. We identified 11 SNPs that exceeded genome-wide significance; the strongest association was for the rs12913832 SNP located on chromosome 15, which has been mapped to the HERC2 gene (p = 6.94 × 10(-14)). Strong associations were also found for SNPs near the ODZ3 and CDH17 genes on chromosomes 4 and

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • occupational respiratory risk and protective measures Moderate

    Occupational health assessment and personalized respiratory protection planning leverages genetic risk stratification to prevent asthma in susceptible workers

    Discuss genetic risk and occupational exposure with occupational health physician for personalized protection planning

Lifestyle

  • occupational diisocyanate exposure Moderate

    G risk allele substantially increases susceptibility to diisocyanate-induced occupational asthma through altered immune response to industrial chemical exposure

    Avoid or minimize occupational diisocyanate exposure through job modification or respiratory protection

Screening

  • pulmonary function if diisocyanate-exposed Moderate

    Regular spirometry and symptom monitoring can detect early airway changes in G allele carriers with occupational diisocyanate exposure

    Annual spirometry and respiratory symptom assessment if occupationally exposed to diisocyanates