rs118078182 - COL23A1

Magnitude 4.5 · 1 study on file

Reported associations

• Genome-wide variants of Eurasian facial shape differentiation and a prospective model of DNA based face prediction. - Journal of genetics and genomics = Yi chuan xue bao (2019) · Qiao L, Yang Y, Fu P, Hu S, Zhou H, Peng S, Tan J, Lu Y, Lou H, Lu D, Wu S, Guo J, Jin L, Guan Y, Wang S, Xu S, Tang K · PubMed 30174134

  It is a long-standing question as to which genes define the characteristic facial features among different ethnic groups. In this study, we use Uyghurs, an ancient admixed population to query the genetic bases why Europeans and Han Chinese look different. Facial traits were analyzed based on high-dense 3D facial images; numerous biometric spaces were examined for divergent facial features between European and Han Chinese, ranging from inter-landmark distances to dense shape geometrics. Genome-wide association studies (GWAS) were conducted on a discovery panel of Uyghurs. Six significant loci were identified, four of which, rs1868752, rs118078182, rs60159418 at or near UBASH3B, COL23A1, PCDH7 and rs17868256 were replicated in independent cohorts of Uyghurs or Southern Han Chinese. A prosp

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