rs118056222 - IMP3P1 - LINC03131
Magnitude 4.5 · 1 study on file
Reported associations
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A genome-wide study on gene-nutrient interactions for hyperuricemia in a large Korean cohort (KoGES) - Unknown journal (n.d.) · Unknown authors · PubMed 40835619
ABSTRACT: This study aimed to identify novel genetic variants associated with hyperuricemia risk across multiple nutrients by assessing significant gene-nutrient interactions using large-scale genome-wide association study (GWAS) data in the Korean population. A total of 48,007 individuals from the Korean Genome and Epidemiology Study dataset were included in the GWAS. Dietary intake was evaluated using a food frequency questionnaire. To identify genomic loci that interact with specific nutrients influencing hyperuricemia risk, we conducted a GWAS followed by gene-nutrient interaction analyses of genome-wide significant single-nucleotide polymorphisms (SNPs). Two SNPs with significant gene-nutrient interactions for specific nutrients were identified: rs113206751 in the Membrane-Assoc
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Diet
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excessive high-potassium food intake Moderate
C allele carriers show 3.75-fold increased hyperuricemia risk with high potassium intake
Limit high-potassium foods such as bananas, beans, nuts, leafy greens, and potatoes
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vitamin E intake Moderate
C allele carriers show 2.52-fold increased hyperuricemia risk with low vitamin E intake
Ensure adequate vitamin E intake through nuts, seeds, oils, or consider supplementation